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    Convalescent plasma with a high level of virus-specific antibody effectively neutralizes SARS-CoV-2 variants of concern

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    Authors
    Li, Maggie
    Gerber, Jonathan M.
    Sullivan, David J
    UMass Chan Affiliations
    Department of Medicine, Division of Hematology Oncology
    Document Type
    Journal Article
    Publication Date
    2022-04-20
    Keywords
    SARS-Co-V2
    variants
    monoclonal antibody therapies
    Covid-19
    convalescent plasma
    Fluids and Secretions
    Hematology
    Hemic and Immune Systems
    Immunology and Infectious Disease
    Infectious Disease
    Microbiology
    Therapeutics
    Virus Diseases
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023079/
    Abstract
    The ongoing evolution of SARS-Co-V2 variants to omicron severely limits available effective monoclonal antibody therapies. Effective drugs are also supply limited. Covid-19 convalescent plasma (CCP) qualified for high antibody levels effectively reduces immunocompetent outpatient hospitalization. The FDA currently allows outpatient CCP for the immunosuppressed. Viral specific antibody levels in CCP can range ten- to hundred-fold between donors unlike the uniform viral specific monoclonal antibody dosing. Limited data are available on the efficacy of polyclonal CCP to neutralize variants. We examined 108 pre-delta/pre-omicron donor units obtained before March 2021, 20 post-delta COVID-19/post-vaccination units and one pre-delta/pre-omicron hyperimmunoglobulin preparation for variant specific virus (vaccine-related isolate (WA-1), delta and omicron) neutralization correlated to Euroimmun S1 IgG antibody levels. We observed a 2- to 4-fold and 20- to 40-fold drop in virus neutralization from SARS-CoV-2 WA-1 to delta or omicron, respectively. CCP antibody levels in the upper 10% of the 108 donations as well as 100% of the post-delta COVID-19/post-vaccination units and the hyperimmunoglobulin effectively neutralized all three variants. High-titer CCP neutralizes SARS-CoV-2 variants despite no previous donor exposure to the variants.
    Source

    Li M, Beck EJ, Laeyendecker O, Eby Y, Tobian AA, Caturegli P, Wouters C, Chiklis GR, Block W, McKie RO, Joyner MJ, Wiltshire TD, Dietz AB, Gniadek TJ, Shapiro AS, Yarava A, Lane K, Hanley DF, Bloch EM, Shoham S, Cachay ER, Meisenberg BR, Huaman MA, Fukuta Y, Patel B, Heath SL, Levine AC, Paxton JH, Anjan S, Gerber JM, Gebo KA, Casadevall A, Pekosz A, Sullivan DJ. Convalescent plasma with a high level of virus-specific antibody effectively neutralizes SARS-CoV-2 variants of concern. Blood Adv. 2022 Apr 20:bloodadvances.2022007410. doi: 10.1182/bloodadvances.2022007410. Epub ahead of print. PMID: 35443020; PMCID: PMC9023079. Link to article on publisher's site

    DOI
    10.1182/bloodadvances.2022007410
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/27652
    PubMed ID
    35443020
    Notes

    Full author list omitted for brevity. For the full list of authors, see article.

    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1182/bloodadvances.2022007410
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