Lessons from the Field: Parasite DNA Drives the Innate Immune Response to Malaria (it's not just the caiparinhas)

Golenbock, Douglas

dc.contributor.author	Golenbock, Douglas
dc.date	2022-08-11T08:08:12.000
dc.date.accessioned	2022-08-23T15:46:13Z
dc.date.available	2022-08-23T15:46:13Z
dc.date.issued	2011-05-20
dc.date.submitted	2011-08-05
dc.identifier.doi	10.13028/qqg6-2298
dc.identifier.uri	http://hdl.handle.net/20.500.14038/27704
dc.description.abstract	The World Health Organization reported 780,000 deaths due to malaria in 2009, mostly in children under 5 years of age residing in 106 countries in Africa, Asia and Latin America. Even though there have been impressive global strides to increase the delivery of malaria interventions such as insecticide treated bednets, rapid diagnostic tests, antimalarial drugs and indoor residual spraying - every 40 seconds a child still dies from malaria. In order to make further progress toward malaria eradication, a better understanding of the dynamic relationship between the Plasmodium parasite and its human host is required. Since malaria has such a complex life cycle, research on malaria is often multifaceted. The research presented focused on understanding how malaria is recognized by innate immune cells that may shape adaptive immunity and combined inform malaria vaccine design strategies. In addition, the parasite genetically adapts to environmental pressures such as antimalarial drugs, further thwarting eradication efforts.
dc.format	youtube
dc.language.iso	en_US
dc.rights	Copyright the Author(s)
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subject	Clinical Epidemiology
dc.subject	Immune System Diseases
dc.subject	Infectious Disease
dc.subject	International Public Health
dc.subject	Public Health
dc.title	Lessons from the Field: Parasite DNA Drives the Innate Immune Response to Malaria (it's not just the caiparinhas)
dc.type	Presentation
dc.identifier.legacyfulltext	https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1008&context=cts_retreat&unstamped=1
dc.identifier.legacycoverpage	https://escholarship.umassmed.edu/cts_retreat/2011/presentations/10
dc.identifier.contextkey	2134868
refterms.dateFOA	2022-08-24T03:21:18Z
html.description.abstract	<p>The World Health Organization reported 780,000 deaths due to malaria in 2009, mostly in children under 5 years of age residing in 106 countries in Africa, Asia and Latin America. Even though there have been impressive global strides to increase the delivery of malaria interventions such as insecticide treated bednets, rapid diagnostic tests, antimalarial drugs and indoor residual spraying - every 40 seconds a child still dies from malaria. In order to make further progress toward malaria eradication, a better understanding of the dynamic relationship between the <em>Plasmodium</em> parasite and its human host is required.</p> <p>Since malaria has such a complex life cycle, research on malaria is often multifaceted. The research presented focused on understanding how malaria is recognized by innate immune cells that may shape adaptive immunity and combined inform malaria vaccine design strategies. In addition, the parasite genetically adapts to environmental pressures such as antimalarial drugs, further thwarting eradication efforts.</p>
dc.identifier.submissionpath	cts_retreat/2011/presentations/10