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dc.contributor.authorLee, Nancy
dc.contributor.authorNicoloro, Sarah M.
dc.contributor.authorStraubhaar, Juerg R.
dc.contributor.authorDarrigo, Melinda
dc.contributor.authorTam, Stanley
dc.contributor.authorCzech, Michael P.
dc.contributor.authorFitzgibbons, Timothy P.
dc.date2022-08-11T08:08:13.000
dc.date.accessioned2022-08-23T15:46:43Z
dc.date.available2022-08-23T15:46:43Z
dc.date.issued2013-05-08
dc.date.submitted2013-07-16
dc.identifier.doi10.13028/myjj-e755
dc.identifier.urihttp://hdl.handle.net/20.500.14038/27816
dc.description<p>Nancy Lee participated in this study as a medical student in the Senior Scholars research program at the University of Massachusetts Medical School.</p>
dc.description.abstractBackground: In patients with coronary artery disease (CAD), epicardial adipose tissue (EAT) expression of inflammatory genes is high while expression of anti-inflammatory genes is low. We hypothesized that expression of certain genes in EAT would correlate directly with the degree of adjacent CAD. Methods: EAT and paired subcutaneous adipose tissue (SAT) samples were collected from cardiac surgery patients (n=9) with and without CAD. RNA was isolated and hybridized to Affymetrix 1.0 ST chips. Genes differentially expressed in EAT vs. SAT were identified. Probe intensities were correlated with the severity of CAD in each patient using the Gensini score. Results: 35 genes were differentially expressed in EAT at >3.0 fold change (p Conclusions: Expression of ITGB8 is directly correlated with CAD severity. ITGB8 has been previously shown to be expressed by fibroblasts and functions to activate TGFβ. TGFβ signaling has also been correlated with advanced atherosclerosis. We speculate that EAT expression of ITGB8 may have pro-inflammatory effects, possibly by activating TGFβ, and stimulating recruitment of dendritic cells or T cells to secondary lymphoid organs in EAT. Whether or not this is the case is a goal of future studies.
dc.formatflash_audio
dc.language.isoen_US
dc.rightsCopyright the Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subjectCardiology
dc.subjectCardiovascular Diseases
dc.subjectMolecular Genetics
dc.subjectTranslational Medical Research
dc.titleExpression of the Integrin Beta 8 Gene (ITGB8) in Epicardial Adipose Tissue is Highly and Directly Correlated with the Degree of Coronary Atherosclerosis
dc.typePoster Abstract
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1145&amp;context=cts_retreat&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/cts_retreat/2013/posters/36
dc.identifier.contextkey4319653
refterms.dateFOA2022-08-23T15:46:43Z
html.description.abstract<p>Background: In patients with coronary artery disease (CAD), epicardial adipose tissue (EAT) expression of inflammatory genes is high while expression of anti-inflammatory genes is low. We hypothesized that expression of certain genes in EAT would correlate directly with the degree of adjacent CAD.</p> <p>Methods: EAT and paired subcutaneous adipose tissue (SAT) samples were collected from cardiac surgery patients (n=9) with and without CAD. RNA was isolated and hybridized to Affymetrix 1.0 ST chips. Genes differentially expressed in EAT vs. SAT were identified. Probe intensities were correlated with the severity of CAD in each patient using the Gensini score.</p> <p>Results: 35 genes were differentially expressed in EAT at >3.0 fold change (p</p> <p>Conclusions: Expression of ITGB8 is directly correlated with CAD severity. ITGB8 has been previously shown to be expressed by fibroblasts and functions to activate TGFβ. TGFβ signaling has also been correlated with advanced atherosclerosis. We speculate that EAT expression of ITGB8 may have pro-inflammatory effects, possibly by activating TGFβ, and stimulating recruitment of dendritic cells or T cells to secondary lymphoid organs in EAT. Whether or not this is the case is a goal of future studies.</p>
dc.identifier.submissionpathcts_retreat/2013/posters/36


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