Show simple item record

dc.contributor.authorXu, Jianwen
dc.contributor.authorFeng, Ellva
dc.contributor.authorSong, Jie
dc.date2022-08-11T08:08:13.000
dc.date.accessioned2022-08-23T15:47:05Z
dc.date.available2022-08-23T15:47:05Z
dc.date.issued2014-05-20
dc.date.submitted2014-10-10
dc.identifier.doi10.13028/gpxy-cm45
dc.identifier.urihttp://hdl.handle.net/20.500.14038/27900
dc.description<p>Abstract of poster presented at the 2014 UMass Center for Clinical and Translational Science Research Retreat, held on May 20, 2014 at the University of Massachusetts Medical School, Worcester, Mass.</p>
dc.description.abstractCytocompatible hydrogels with good mechanical properties and predictable degradation are highly desired for many biomedical applications including stem cell and therapeutics delivery for guided tissue repair. However, existing methods for fabricating tough hydrogels usually involve non-physiological conditions, such as toxic starting materials, catalysts, or crosslinking chemistry. Moreover, precisely controlling hydrogel degradation over a broad range in a predictable manner has been extremely challenging while empirical tuning of most degradable materials’ degradation profiles often resulting in undesired changes in other properties. To solve these problems, we recently developed a versatile hydrogel formulation that allows us to fabricate cytocompatible tough hydrogels under physiological conditions with predicable and widely tunable degradations. This platform was based on a well-defined hydrogel network formed by two pairs of four-armed poly(ethylene glycol) macromers terminated with bioorthogonal azide and dibenzocyclooctyl endgroups, respectively, via labile or stable linkages. The high-fidelity, catalyst-free bioorthogonal crosslinking reaction between these pairs of macromers enabled robust crosslinking in water, phosphate buffered saline and cell culture media to afford tough hydrogels capable of withstanding >90% compressive strain. The strategic placement of labile ester linkages near the crosslinking site within this superhydrophilic network, accomplished by facile adjustments of the ratio of the macromers used, enabled broad tuning of the hydrogel disintegration rates from 2 days to >250 days that precisely matched with the theoretical prediction based on a first-order linkage cleavage kinetics. This platform holds great potential for many biomedical applications that demands cytocompatability, adequate mechanical integrity and precisely controlled temporal disintegration of the synthetic matrix.
dc.formatyoutube
dc.language.isoen_US
dc.rightsCopyright the Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subjectBiomedical Engineering and Bioengineering
dc.subjectCell and Developmental Biology
dc.subjectMolecular, Cellular, and Tissue Engineering
dc.subjectOrthopedics
dc.subjectTranslational Medical Research
dc.titleCytocompatible Tough Hydrogel Platform with Predictable Degradation
dc.typePoster Abstract
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1330&amp;context=cts_retreat&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/cts_retreat/2014/posters/110
dc.identifier.contextkey6226208
refterms.dateFOA2022-08-23T15:47:05Z
html.description.abstract<p>Cytocompatible hydrogels with good mechanical properties and predictable degradation are highly desired for many biomedical applications including stem cell and therapeutics delivery for guided tissue repair. However, existing methods for fabricating tough hydrogels usually involve non-physiological conditions, such as toxic starting materials, catalysts, or crosslinking chemistry. Moreover, precisely controlling hydrogel degradation over a broad range in a predictable manner has been extremely challenging while empirical tuning of most degradable materials’ degradation profiles often resulting in undesired changes in other properties. To solve these problems, we recently developed a versatile hydrogel formulation that allows us to fabricate cytocompatible tough hydrogels under physiological conditions with predicable and widely tunable degradations. This platform was based on a well-defined hydrogel network formed by two pairs of four-armed poly(ethylene glycol) macromers terminated with bioorthogonal azide and dibenzocyclooctyl endgroups, respectively, via labile or stable linkages. The high-fidelity, catalyst-free bioorthogonal crosslinking reaction between these pairs of macromers enabled robust crosslinking in water, phosphate buffered saline and cell culture media to afford tough hydrogels capable of withstanding >90% compressive strain. The strategic placement of labile ester linkages near the crosslinking site within this superhydrophilic network, accomplished by facile adjustments of the ratio of the macromers used, enabled broad tuning of the hydrogel disintegration rates from 2 days to >250 days that precisely matched with the theoretical prediction based on a first-order linkage cleavage kinetics. This platform holds great potential for many biomedical applications that demands cytocompatability, adequate mechanical integrity and precisely controlled temporal disintegration of the synthetic matrix.</p>
dc.identifier.submissionpathcts_retreat/2014/posters/110


Files in this item

Thumbnail
Name:
Xu.pdf
Size:
16.68Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

Copyright the Author(s)
Except where otherwise noted, this item's license is described as Copyright the Author(s)