Interactions of Carbohydrate-conjugated Nanoparticles with Mycobacterium Smegmatis
Document Type
Poster AbstractPublication Date
2014-05-20Keywords
Bacterial Infections and MycosesChemical and Pharmacologic Phenomena
Medicinal-Pharmaceutical Chemistry
Nanomedicine
Translational Medical Research
Metadata
Show full item recordAbstract
Mycobacterium smegmatis is a non-pathogenic microorganism and has been widely used as a model organism to study infections caused by M. tuberculosis and other mycobacterial pathogens. We report that nanoparticles conjugated with selected carbohydrate show a striking increase in the surface adherence by M. smegmatis. This applies to silica nanoparticles and magnetic nanoparticles ranging from 100 nm to 5 nm. Under the same experimental conditions, minimum adhesion was observed for unfunctionalized nanoparticles. The synthesis and characterization of the glyconanoparticles will be presented. The finding is applied to imaging M. smegmatis infected lung epithelial cells, and the results will be discussed.DOI
10.13028/b3r7-h289Permanent Link to this Item
http://hdl.handle.net/20.500.14038/27965Notes
Abstract of poster presented at the 2014 UMass Center for Clinical and Translational Science Research Retreat, held on May 20, 2014 at the University of Massachusetts Medical School, Worcester, Mass.
Rights
Copyright the Author(s)Distribution License
http://creativecommons.org/licenses/by-nc-sa/3.0/ae974a485f413a2113503eed53cd6c53
10.13028/b3r7-h289