Testosterone Treatment Does Not Facilitate Prefrontal Cortex Mediated Cognition in Male Marmosets (callithrix jacchus)

LaClair, Matthew; Chang, Jeemin; Lacreuse, Agnes

dc.contributor.author	LaClair, Matthew
dc.contributor.author	Chang, Jeemin
dc.contributor.author	Lacreuse, Agnes
dc.date	2022-08-11T08:08:14.000
dc.date.accessioned	2022-08-23T15:47:27Z
dc.date.available	2022-08-23T15:47:27Z
dc.date.issued	2014-05-20
dc.date.submitted	2014-10-10
dc.identifier.doi	10.13028/afrp-8j96
dc.identifier.uri	http://hdl.handle.net/20.500.14038/27989
dc.description	<p>Abstract of poster presented at the 2014 UMass Center for Clinical and Translational Science Research Retreat, held on May 20, 2014 at the University of Massachusetts Medical School, Worcester, Mass.</p>
dc.description.abstract	Aging in men is associated with decreases in serum testosterone (T) and a decline in cognitive abilities. We sought to clarify the relationship between T, aging and cognition using the common marmoset (callithrix jacchus), which has been shown to be a useful model of human aging. Ten castrated male marmosets (ages 3-8) were given weekly injections of either T cypionate dissolved in cottonseed oil (T, n = 5) or cottonseed oil alone (controls, n = 5). Cognitive function was assessed with two tasks, the object reversals (OR) and the delayed response (DR). Marmoset behavior was recorded twice daily using a modified frequency scoring system, measuring 20 target behaviors in 15-s intervals over 5-min. For the OR task, no effect of group (F (1,8) = .51, p = .50), reversal (F (3,24) = .527, p = .67), or group x reversal interactions (F (3,24) = .640, p = .60) was found in the number of correct trials. There was a significant effect of outcome on response latency, with all monkeys having longer latencies on incorrect trials (F (1,2451) = 45.36, p
dc.format	youtube
dc.language.iso	en_US
dc.rights	Copyright the Author(s)
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subject	Behavioral Neurobiology
dc.subject	Cognitive Neuroscience
dc.subject	Hormones, Hormone Substitutes, and Hormone Antagonists
dc.subject	Polycyclic Compounds
dc.subject	Translational Medical Research
dc.title	Testosterone Treatment Does Not Facilitate Prefrontal Cortex Mediated Cognition in Male Marmosets (callithrix jacchus)
dc.type	Poster Abstract
dc.identifier.legacyfulltext	https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1293&context=cts_retreat&unstamped=1
dc.identifier.legacycoverpage	https://escholarship.umassmed.edu/cts_retreat/2014/posters/73
dc.identifier.contextkey	6225222
refterms.dateFOA	2022-08-23T15:47:27Z
html.description.abstract	<p>Aging in men is associated with decreases in serum testosterone (T) and a decline in cognitive abilities. We sought to clarify the relationship between T, aging and cognition using the common marmoset (callithrix jacchus), which has been shown to be a useful model of human aging. Ten castrated male marmosets (ages 3-8) were given weekly injections of either T cypionate dissolved in cottonseed oil (T, n = 5) or cottonseed oil alone (controls, n = 5). Cognitive function was assessed with two tasks, the object reversals (OR) and the delayed response (DR). Marmoset behavior was recorded twice daily using a modified frequency scoring system, measuring 20 target behaviors in 15-s intervals over 5-min. For the OR task, no effect of group (F (1,8) = .51, p = .50), reversal (F (3,24) = .527, p = .67), or group x reversal interactions (F (3,24) = .640, p = .60) was found in the number of correct trials. There was a significant effect of outcome on response latency, with all monkeys having longer latencies on incorrect trials (F (1,2451) = 45.36, p</p>
dc.identifier.submissionpath	cts_retreat/2014/posters/73