Feasibility, Safety and Acceptability of Soy-Based Diet for Pregnant Women: Preliminary Results from a Pilot Randomized Controlled Trial
dc.contributor.author | Shi, Ling | |
dc.contributor.author | Iyer, Vidya | |
dc.contributor.author | Norwitz, Errol | |
dc.contributor.author | Moore Simas, Tiffany A. | |
dc.contributor.author | Matthan, Nirupa R. | |
dc.contributor.author | Lichtenstein, Alice H. | |
dc.contributor.author | Hayman, Laura L. | |
dc.date | 2022-08-11T08:08:16.000 | |
dc.date.accessioned | 2022-08-23T15:48:31Z | |
dc.date.available | 2022-08-23T15:48:31Z | |
dc.date.issued | 2017-05-16 | |
dc.date.submitted | 2017-06-29 | |
dc.identifier.doi | 10.13028/qs45-sn27 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/28227 | |
dc.description.abstract | Background: Previous evidence suggests that soy containing foods may have beneficial effects on lipid and glycemic metabolism. Pregnancy is associated with a progressive deterioration in glucose and lipid metabolism, partially attributable to elevated estrogen concentrations. Little is known about the effects of soy intake on cardiometabolic risk factors in pregnant women. Methods: A pilot RCT was conducted in 30 pregnant women who were randomized to receive counseling to consume a high-soy or low-soy foods containing diet. Assessments (physical measurements, food frequency questionnaires, fasting blood samples) were conducted at 14 and 28 weeks of pregnancy, and 6 weeks’ postpartum. Monthly follow-up calls were conducted to assess safety and encourage adherence. Results: Both the high-soy and low-soy groups demonstrated high adherence (80-90%), defined as consuming soy foods ≥ 15 days in the past four weeks for high-soy group and ≤ 5 days for low-soy group. Five adverse events possibly associated with soy intake were reported (nausea, vomiting, diarrhea, itchy mouth); all were transient and resolved without sequelae. The high-soy group lost body fat between baseline and postpartum while the low-soy group gained body fat, as reflected by change in triceps skinfold thickness (-4.8 mm vs +3.6 mm, p=0.04). There was a trend towards an improvement in BMI in the high-soy group, both at 28 weeks (+1.4 vs. +3.6 kg/m2, p=0.15) and postpartum (-1.2 vs. +0.6 kg/m2, p=0.14). There were no differences between groups in fasting glucose, HDL-C, LDL-C, TG, or VLDL levels. Conclusion: Initial results from this pilot RCT support the acceptability and safety of consuming soy-based whole foods during pregnancy. A larger-scale RCT is needed to further elucidate the effects of soy diet on cardiometabolic risk among pregnant women. | |
dc.format | flash_audio | |
dc.language.iso | en_US | |
dc.rights | Copyright the Author(s) | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/ | |
dc.subject | pregnant women | |
dc.subject | diet | |
dc.subject | soy | |
dc.subject | cardiometabolic risk factors | |
dc.subject | Dietetics and Clinical Nutrition | |
dc.subject | Maternal and Child Health | |
dc.subject | Obstetrics and Gynecology | |
dc.subject | Translational Medical Research | |
dc.subject | Women's Health | |
dc.title | Feasibility, Safety and Acceptability of Soy-Based Diet for Pregnant Women: Preliminary Results from a Pilot Randomized Controlled Trial | |
dc.type | Poster Abstract | |
dc.identifier.legacyfulltext | https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1565&context=cts_retreat&unstamped=1 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/cts_retreat/2017/posters/72 | |
dc.identifier.contextkey | 10379724 | |
refterms.dateFOA | 2022-08-23T15:48:31Z | |
html.description.abstract | <p><strong>Background: </strong>Previous evidence suggests that soy containing foods may have beneficial effects on lipid and glycemic metabolism. Pregnancy is associated with a progressive deterioration in glucose and lipid metabolism, partially attributable to elevated estrogen concentrations. Little is known about the effects of soy intake on cardiometabolic risk factors in pregnant women.</p> <p><strong>Methods: </strong> A pilot RCT was conducted in 30 pregnant women who were randomized to receive counseling to consume a high-soy or low-soy foods containing diet. Assessments (physical measurements, food frequency questionnaires, fasting blood samples) were conducted at 14 and 28 weeks of pregnancy, and 6 weeks’ postpartum. Monthly follow-up calls were conducted to assess safety and encourage adherence.</p> <p><strong>Results: </strong>Both the high-soy and low-soy groups demonstrated high adherence (80-90%), defined as consuming soy foods ≥ 15 days in the past four weeks for high-soy group and ≤ 5 days for low-soy group. Five adverse events possibly associated with soy intake were reported (nausea, vomiting, diarrhea, itchy mouth); all were transient and resolved without sequelae. The high-soy group lost body fat between baseline and postpartum while the low-soy group gained body fat, as reflected by change in triceps skinfold thickness (-4.8 mm vs +3.6 mm, p=0.04). There was a trend towards an improvement in BMI in the high-soy group, both at 28 weeks (+1.4 vs. +3.6 kg/m<sup>2</sup>, p=0.15) and postpartum (-1.2 vs. +0.6 kg/m<sup>2</sup>, p=0.14). There were no differences between groups in fasting glucose, HDL-C, LDL-C, TG, or VLDL levels.</p> <p><strong>Conclusion: </strong>Initial results from this pilot RCT support the acceptability and safety of consuming soy-based whole foods during pregnancy. A larger-scale RCT is needed to further elucidate the effects of soy diet on cardiometabolic risk among pregnant women.</p> | |
dc.identifier.submissionpath | cts_retreat/2017/posters/72 |