Data from: Lactose Intolerance: Lack of Evidence for Short Stature or Vitamin D Deficiency in Prepubertal Children
dc.contributor.author | Setty-Shah, Nithya | |
dc.contributor.author | Maranda, Louise S. | |
dc.contributor.author | Candela, Ninfa | |
dc.contributor.author | Fong, Jay G. | |
dc.contributor.author | Dahod, Idris | |
dc.contributor.author | Rogol, Alan D. | |
dc.contributor.author | Nwosu, Benjamin U. | |
dc.date | 2022-08-11T08:08:16.000 | |
dc.date.accessioned | 2022-08-23T15:48:44Z | |
dc.date.available | 2022-08-23T15:48:44Z | |
dc.date.issued | 2013-08-07 | |
dc.date.submitted | 2013-08-08 | |
dc.identifier.doi | 10.13028/rv7q-hz18 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/28274 | |
dc.description | <p>This dataset (.csv file, 11 KB) is the primary data source for the following published study: Setty-Shah N, Maranda L, Candela N, Fong J, Dahod I, et al. (2013) Lactose Intolerance: <a href="http://escholarship.umassmed.edu/peds_endocrinology/43/" target="_blank">Lack of Evidence for Short Stature or Vitamin D Deficiency in Prepubertal Children</a>. PLoS ONE 8(10): e78653. doi:10.1371/journal.pone.0078653</p> | |
dc.description.abstract | Background: The health consequences of lactose intolerance (LI) are unclear. Aims: To investigate the effects of LI on stature and vitamin D status. Hypotheses: LI subjects will have similar heights and vitamin D status as controls. Subjects and Methods: Prepubertal children of ages 3-12 years with LI (n=38, age 8.61 ± 3.08y, male/female 19/19) were compared to healthy, age- and gender-matched controls (n=49, age 7.95±2.64, male/female 28/21). Inclusion criteria: prepubertal status (boys: testicular volume Results: There was no significant difference in 25(OH)D between the LI and non-LI subjects (60.1±21.1, vs. 65.4 ± 26.1 nmol/L, p = 0.29). Upon stratification into normal weight (BMI percentile) vs. overweight/obese (BMI ≥85th percentile), the normal weight controls had significantly higher 25(OH)D level than both the normal weight LI children (78.3 ± 32.6 vs. 62.9 ± 23.2, p = 0.025), and the overweight/obese LI children (78.3±32.6 vs. 55.3±16.5, p = 0.004). Secondly, there was no overall difference in height z-score between the LI children and controls. The normal weight LI patients had similar height as normal controls (-0.46 ± 0.89 vs. -0.71 ± 1.67, p = 0.53), while the overweight/obese LI group was taller than the normal weight controls (0.36 ± 1.41 vs. -0.71 ± 1.67, p = 0.049), and of similar height as the overweight/obese controls (0.36 ± 1.41 vs. 0.87 ± 1.45, p = 0.28). MPTH z-score was similar between the groups. Conclusion: Short stature and vitamin D deficiency are not features of LI in prepubertal children. | |
dc.language.iso | en_US | |
dc.publisher | eScholarship@UMMS | |
dc.rights | Copyright © 2013 The Author(s) | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Vitamin D deficiency | |
dc.subject | Lactose intolerance | |
dc.subject | Children | |
dc.subject | Obesity | |
dc.subject | Hydrogen | |
dc.subject | Body Mass Index | |
dc.subject | Short stature | |
dc.subject | Endocrinology, Diabetes, and Metabolism | |
dc.subject | Pediatrics | |
dc.title | Data from: Lactose Intolerance: Lack of Evidence for Short Stature or Vitamin D Deficiency in Prepubertal Children | |
dc.type | Dataset | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/datasets/1 | |
dc.identifier.contextkey | 4406896 | |
refterms.dateFOA | 2022-08-23T15:48:44Z | |
html.description.abstract | <p>Background: The health consequences of lactose intolerance (LI) are unclear.</p> <p>Aims: To investigate the effects of LI on stature and vitamin D status.</p> <p>Hypotheses: LI subjects will have similar heights and vitamin D status as controls.</p> <p>Subjects and Methods: Prepubertal children of ages 3-12 years with LI (n=38, age 8.61 ± 3.08y, male/female 19/19) were compared to healthy, age- and gender-matched controls (n=49, age 7.95±2.64, male/female 28/21). Inclusion criteria: prepubertal status (boys: testicular volume</p> <p>Results: There was no significant difference in 25(OH)D between the LI and non-LI subjects (60.1±21.1, vs. 65.4 ± 26.1 nmol/L, <em>p</em> = 0.29). Upon stratification into normal weight (BMI percentile) vs. overweight/obese (BMI ≥85th percentile), the normal weight controls had significantly higher 25(OH)D level than both the normal weight LI children (78.3 ± 32.6 vs. 62.9 ± 23.2, p = 0.025), and the overweight/obese LI children (78.3±32.6 vs. 55.3±16.5, <em>p</em> = 0.004). Secondly, there was no overall difference in height z-score between the LI children and controls. The normal weight LI patients had similar height as normal controls (-0.46 ± 0.89 vs. -0.71 ± 1.67, <em>p</em> = 0.53), while the overweight/obese LI group was taller than the normal weight controls (0.36 ± 1.41 vs. -0.71 ± 1.67, <em>p</em> = 0.049), and of similar height as the overweight/obese controls (0.36 ± 1.41 vs. 0.87 ± 1.45, <em>p</em> = 0.28). MPTH z-score was similar between the groups.</p> <p>Conclusion: Short stature and vitamin D deficiency are not features of LI in prepubertal children.</p> | |
dc.identifier.submissionpath | datasets/1 | |
dc.contributor.department | Department of Quantitative Health Sciences | |
dc.contributor.department | Department of Pediatrics |