Show simple item record

dc.contributor.authorNwosu, Benjamin U.
dc.contributor.authorMaranda, Louise S.
dc.date2022-08-11T08:08:16.000
dc.date.accessioned2022-08-23T15:48:44Z
dc.date.available2022-08-23T15:48:44Z
dc.date.issued2014-05-05
dc.date.submitted2014-05-06
dc.identifier.doi10.13028/knkb-z855
dc.identifier.urihttp://hdl.handle.net/20.500.14038/28275
dc.description<p>This dataset (.xlsx file, 47 KB) is the primary data source for the following published study: Nwosu BU, Maranda L (2014) <a href="http://escholarship.umassmed.edu/peds_endocrinology/46/" target="_blank">The Effects of Vitamin D Supplementation on Hepatic Dysfunction, Vitamin D Status, and Glycemic Control in Children and Adolescents with Vitamin D Deficiency and Either Type 1 or Type 2 Diabetes Mellitus</a>. PLoS ONE 9(6): e99646. doi:10.1371/journal.pone.0099646.</p>
dc.description.abstractBackground: The effects of vitamin D supplementation on mild hepatic dysfunction and glycemic control are unclear in children and adolescents with either type 1 (T1D) or type 2 diabetes (T2D). Hypothesis: Vitamin D supplementation will improve hepatic dysfunction and glycemic control. Aim: To determine the effect of vitamin D supplementation on alanine transaminase (ALT), hemoglobin A1c (HbA1c), and serum 25-hydroxyvitamin D [25(OH)D] concentration. Subjects and Methods: A retrospective study of 131 subjects with either T1D (n=88: 46 females, 42 males), or T2D ( n=43: 26 females, 17 males) of ages 3-18 years between 2007-2013. All subjects had (1) a diagnosis of diabetes for >12 mo, (2) received vitamin D supplementation for the management of vitamin D deficiency (3) had baseline and subsequent simultaneous measurements of HbA1c, ALT, and 25(OH)D. Vitamin D deficiency was defined as 25(OH)D concentration of <50nmol/L (20 ng/mL). Results: At baseline, vitamin D deficiency occurred in 72.1% of patients with T2D and in 37.5% of T1D patients (p Conclusions: Vitamin D supplementation in subjects with T2D was associated with statistically significant decreases in BMI SDS, ALT, and a clinically-significant decrease in HbA1c.
dc.language.isoen_US
dc.publishereScholarship@UMMS
dc.rightsCopyright © 2014 The Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectType 1 diabetes
dc.subjecttype 2 diabetes
dc.subjectvitamin D
dc.subjecthemoglobin A1c
dc.subjectalanine transaminase
dc.subjectliver dysfunction
dc.subjectchildren
dc.subjectadolescents
dc.subjectEndocrinology, Diabetes, and Metabolism
dc.subjectPediatrics
dc.titleData from: The Effects of Vitamin D Supplementation on Hepatic Dysfunction, Vitamin D Status, and Glycemic Control in Children and Adolescents with Vitamin D Deficiency and Either Type 1 or Type 2 Diabetes Mellitus
dc.typeDataset
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/datasets/2
dc.identifier.contextkey5555452
refterms.dateFOA2022-08-23T15:48:44Z
html.description.abstract<p><strong>Background:</strong> The effects of vitamin D supplementation on mild hepatic dysfunction and glycemic control are unclear in children and adolescents with either type 1 (T1D) or type 2 diabetes (T2D).</p> <p><strong>Hypothesis</strong>: Vitamin D supplementation will improve hepatic dysfunction and glycemic control.</p> <p><strong>Aim:</strong> To determine the effect of vitamin D supplementation on alanine transaminase (ALT), hemoglobin A1c (HbA1c), and serum 25-hydroxyvitamin D [25(OH)D] concentration.</p> <p><strong>Subjects and Methods: </strong>A<strong> </strong>retrospective study of 131 subjects with either T1D (n=88: 46 females, 42 males), or T2D ( n=43: 26 females, 17 males) of ages 3-18 years between 2007-2013. All subjects had (1) a diagnosis of diabetes for >12 mo, (2) received vitamin D supplementation for the management of vitamin D deficiency (3) had baseline and subsequent simultaneous measurements of HbA1c, ALT, and 25(OH)D. Vitamin D deficiency was defined as 25(OH)D concentration of <50nmol/L (20 ng/mL).</p> <p><strong>Results: </strong>At baseline, vitamin D deficiency occurred in 72.1% of patients with T2D and in 37.5% of T1D patients (p</p> <p><strong>Conclusions:</strong> Vitamin D supplementation in subjects with T2D was associated with statistically significant decreases in BMI SDS, ALT, and a clinically-significant decrease in HbA1c.</p>
dc.identifier.submissionpathdatasets/2
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.contributor.departmentDepartment of Pediatrics


Files in this item

Thumbnail
Name:
Dataset_Vitamin_D_Supplementat ...
Size:
47.12Kb
Format:
Microsoft Excel 2007

This item appears in the following Collection(s)

Show simple item record

Copyright © 2014 The Author(s)
Except where otherwise noted, this item's license is described as Copyright © 2014 The Author(s)