TNF and MAP kinase signalling pathways
| dc.contributor.author | Sabio, Guadalupe | |
| dc.contributor.author | Davis, Roger J. | |
| dc.date | 2022-08-11T08:08:16.000 | |
| dc.date.accessioned | 2022-08-23T15:48:57Z | |
| dc.date.available | 2022-08-23T15:48:57Z | |
| dc.date.issued | 2014-06-01 | |
| dc.date.submitted | 2016-03-09 | |
| dc.identifier.citation | Semin Immunol. 2014 Jun;26(3):237-45. doi: 10.1016/j.smim.2014.02.009. Epub 2014 Mar 16. <a href="http://dx.doi.org/10.1016/j.smim.2014.02.009">Link to article on publisher's site</a> | |
| dc.identifier.issn | 1044-5323 (Linking) | |
| dc.identifier.doi | 10.1016/j.smim.2014.02.009 | |
| dc.identifier.pmid | 24647229 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/28320 | |
| dc.description.abstract | The binding of tumour necrosis factor alpha (TNFalpha) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun NH2-terminal kinases (JNKs); and the p38 MAP kinases. These MAP kinase signalling pathways induce a secondary response by increasing the expression of several inflammatory cytokines (including TNFalpha) that contribute to the biological activity of TNFalpha. MAP kinases therefore function both upstream and down-stream of signalling by TNFalpha receptors. Here we review mechanisms that mediate these actions of MAP kinases during the response to TNFalpha. | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=24647229&dopt=Abstract">Link to Article in PubMed</a> | |
| dc.relation.url | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099309/ | |
| dc.subject | Animals | |
| dc.subject | Humans | |
| dc.subject | *MAP Kinase Signaling System | |
| dc.subject | Tumor Necrosis Factor-alpha | |
| dc.subject | ERK | |
| dc.subject | JNK | |
| dc.subject | MAP kinase | |
| dc.subject | TNF | |
| dc.subject | p38 MAP kinase | |
| dc.subject | Biochemistry | |
| dc.subject | Cell Biology | |
| dc.subject | Cellular and Molecular Physiology | |
| dc.subject | Molecular Biology | |
| dc.title | TNF and MAP kinase signalling pathways | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Seminars in immunology | |
| dc.source.volume | 26 | |
| dc.source.issue | 3 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/davis/48 | |
| dc.identifier.contextkey | 8293924 | |
| html.description.abstract | <p>The binding of tumour necrosis factor alpha (TNFalpha) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun NH2-terminal kinases (JNKs); and the p38 MAP kinases. These MAP kinase signalling pathways induce a secondary response by increasing the expression of several inflammatory cytokines (including TNFalpha) that contribute to the biological activity of TNFalpha. MAP kinases therefore function both upstream and down-stream of signalling by TNFalpha receptors. Here we review mechanisms that mediate these actions of MAP kinases during the response to TNFalpha.</p> | |
| dc.identifier.submissionpath | davis/48 | |
| dc.contributor.department | Program in Molecular Medicine | |
| dc.source.pages | 237-45 |
Files in this item
Name:
Publisher version