Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1
Jung, Dae Young
Ko, Hwi Jin
Kim, Jason K.
Davis, Roger J.
UMass Chan AffiliationsProgram in Molecular Medicine
Document TypeJournal Article
MetadataShow full item record
AbstractThe cJun N-terminal kinase 1 (JNK1) is implicated in diet-induced obesity. Indeed, germline ablation of the murine Jnk1 gene prevents diet-induced obesity. Here we demonstrate that selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. The failure to increase body mass is mediated, in part, by increased energy expenditure that is associated with activation of the hypothalamic-pituitary-thyroid axis. Disruption of thyroid hormone function prevents the effects of nervous system JNK1 deficiency on body mass. These data demonstrate that the hypothalamic-pituitary-thyroid axis represents an important target of metabolic signaling by JNK1.
SourceGenes Dev. 2010 Feb 1;24(3):256-64. doi: 10.1101/gad.1878510. Epub 2010 Jan 15. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/28355
Related ResourcesLink to Article in PubMed
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