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dc.contributor.authorBerny-Lang, M. A.
dc.contributor.authorDarling, Chad E.
dc.contributor.authorFrelinger, Andrew L. 3rd
dc.contributor.authorBarnard, Mark R.
dc.contributor.authorSmith, Craig S.
dc.contributor.authorMichelson, Alan D.
dc.date2022-08-11T08:08:17.000
dc.date.accessioned2022-08-23T15:49:32Z
dc.date.available2022-08-23T15:49:32Z
dc.date.issued2015-02-01
dc.date.submitted2018-01-22
dc.identifier.citation<p>Int J Lab Hematol. 2015 Feb;37(1):112-9. doi: 10.1111/ijlh.12250. Epub 2014 May 8. <a href="https://doi.org/10.1111/ijlh.12250">Link to article on publisher's site</a></p>
dc.identifier.issn1751-5521 (Linking)
dc.identifier.doi10.1111/ijlh.12250
dc.identifier.pmid24806286
dc.identifier.urihttp://hdl.handle.net/20.500.14038/28458
dc.description.abstractINTRODUCTION: Early and accurate identification of acute coronary syndrome (ACS) vs. noncardiac chest pain in patients presenting to the emergency department (ED) is problematic and new diagnostic markers are needed. Previous studies reported that elevated mean platelet volume (MPV) is associated with ACS and predictive of cardiovascular risk. MPV is closely related to the immature platelet fraction (IPF), and recent studies have suggested that IPF may be a more sensitive marker of ACS than MPV. The objective of the present study was to determine whether the measurement of IPF assists in the diagnosis of ACS in patients presenting to the ED with chest pain. METHODS: In this single-center, prospective, cross-sectional study, adult patients presenting to the ED with chest pain and/or suspected ACS were considered for enrollment. Blood samples from 236 ACS-negative and 44 ACS-positive patients were analyzed in a Sysmex XE-2100 for platelet count, MPV, IPF, and the absolute count of immature platelets (IPC). RESULTS: Total platelet counts, MPV, IPF, and IPC were not statistically different between ACS-negative and ACS-positive patients. The IPF was 4.6 +/- 2.7% and 5.0 +/- 2.8% (mean +/- SD, P = 0.24), and the IPC was 10.0 +/- 4.6 and 11.5 +/- 7.5 x 10(3) /muL (P = 0.27) for ACS-negative and ACS-positive patients, respectively. CONCLUSION: In 280 patients presenting to the ED with chest pain and/or suspected ACS, no differences in IPF, IPC or MPV were observed in ACS-negative vs. ACS-positive patients, suggesting that these parameters do not assist in the diagnosis of ACS.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=24806286&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225001/
dc.subjectAcute coronary syndrome
dc.subjectemergency medicine
dc.subjectimmature platelet fraction
dc.subjectmyocardial infarction
dc.subjectplatelets
dc.subjectCardiology
dc.subjectCardiovascular Diseases
dc.subjectEmergency Medicine
dc.subjectHematology
dc.titleDo immature platelet levels in chest pain patients presenting to the emergency department aid in the diagnosis of acute coronary syndrome
dc.typeJournal Article
dc.source.journaltitleInternational journal of laboratory hematology
dc.source.volume37
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/emed_pp/144
dc.identifier.contextkey11400593
html.description.abstract<p>INTRODUCTION: Early and accurate identification of acute coronary syndrome (ACS) vs. noncardiac chest pain in patients presenting to the emergency department (ED) is problematic and new diagnostic markers are needed. Previous studies reported that elevated mean platelet volume (MPV) is associated with ACS and predictive of cardiovascular risk. MPV is closely related to the immature platelet fraction (IPF), and recent studies have suggested that IPF may be a more sensitive marker of ACS than MPV. The objective of the present study was to determine whether the measurement of IPF assists in the diagnosis of ACS in patients presenting to the ED with chest pain.</p> <p>METHODS: In this single-center, prospective, cross-sectional study, adult patients presenting to the ED with chest pain and/or suspected ACS were considered for enrollment. Blood samples from 236 ACS-negative and 44 ACS-positive patients were analyzed in a Sysmex XE-2100 for platelet count, MPV, IPF, and the absolute count of immature platelets (IPC).</p> <p>RESULTS: Total platelet counts, MPV, IPF, and IPC were not statistically different between ACS-negative and ACS-positive patients. The IPF was 4.6 +/- 2.7% and 5.0 +/- 2.8% (mean +/- SD, P = 0.24), and the IPC was 10.0 +/- 4.6 and 11.5 +/- 7.5 x 10(3) /muL (P = 0.27) for ACS-negative and ACS-positive patients, respectively.</p> <p>CONCLUSION: In 280 patients presenting to the ED with chest pain and/or suspected ACS, no differences in IPF, IPC or MPV were observed in ACS-negative vs. ACS-positive patients, suggesting that these parameters do not assist in the diagnosis of ACS.</p>
dc.identifier.submissionpathemed_pp/144
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.contributor.departmentDepartment of Emergency Medicine
dc.source.pages112-9


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