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    Cannabinoid toxicity in pediatrics

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    Authors
    Blohm, Eike
    Sell, Peter J.
    Neavyn, Mark J.
    UMass Chan Affiliations
    Department of Emergency Medicine
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    2019-04-01
    Keywords
    cannabinoids
    marijuana
    pediatric
    tetrahydrocannabinol
    toxicity
    Emergency Medicine
    Medical Toxicology
    Pediatrics
    
    Metadata
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    Link to Full Text
    https://doi.org/10.1097/MOP.0000000000000739
    Abstract
    PURPOSE OF REVIEW: The advent of legalized cannabis in multiple regions of the United States has rendered the drug more accessible to pediatric patients. Pediatricians and Pediatric Emergency Medicine Providers face new challenges in counseling both patients and their parents, diagnosing exploratory ingestions of cannabinoids in toddlers, and managing complications of prolonged, heavy cannabis use in adolescents. The purpose of this review article is to provide clinicians a succinct summary of recent literature regarding tetrahydrocannabinol (THC) pharmacokinetics, pharmacodynamics, impacts on development, as well as presentations of acute and chronic toxicity. RECENT FINDINGS: Many young children being admitted to the hospital for cannabis toxicity have been exposed to high concentration products, such as edibles, resins, or vaping fluid. These products contain extremely high concentrations of cannabinoids, and lead to sedation, respiratory depression, and other adverse effects. Chronic toxicity associated with cannabis consumption includes neurocognitive changes and cannabinoid hyperemesis syndrome. SUMMARY: Clinicians should provide guidance for pediatric patients and their caregivers to reduce the risk of accidental cannabis exposure, particularly with high concentration products. In addition, clinicians should consider chronic cannabis exposure when evaluating certain complaints, such as chronic vomiting or educational performance at school.
    Source

    Curr Opin Pediatr. 2019 Apr;31(2):256-261. doi: 10.1097/MOP.0000000000000739. Link to article on publisher's site

    DOI
    10.1097/MOP.0000000000000739
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/28488
    PubMed ID
    30694824
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1097/MOP.0000000000000739
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    UMass Chan Faculty and Researcher Publications
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