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    GW182 controls Drosophila circadian behavior and PDF-receptor signaling

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    Authors
    Zhang, Yong
    Emery, Patrick
    UMass Chan Affiliations
    Emery Lab
    Neurobiology
    Document Type
    Journal Article
    Publication Date
    2013-04-10
    Keywords
    Animals
    Animals, Genetically Modified
    Circadian Rhythm
    Drosophila
    Drosophila Proteins
    Gene Expression Regulation, Developmental
    Green Fluorescent Proteins
    Locomotion
    Male
    MicroRNAs
    RNA Interference
    Receptors, G-Protein-Coupled
    Signal Transduction
    Temperature
    Transcription Factors
    Molecular and Cellular Neuroscience
    Neuroscience and Neurobiology
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    Link to Full Text
    http://dx.doi.org/10.1016/j.neuron.2013.01.035
    Abstract
    The neuropeptide PDF is crucial for Drosophila circadian behavior: it keeps circadian neurons synchronized. Here, we identify GW182 as a key regulator of PDF signaling. Indeed, GW182 downregulation results in phenotypes similar to those of Pdf and Pdf-receptor (Pdfr) mutants. gw182 genetically interacts with Pdfr and cAMP signaling, which is essential for PDFR function. GW182 mediates miRNA-dependent gene silencing through its interaction with AGO1. Consistently, GW182's AGO1 interaction domain is required for GW182's circadian function. Moreover, our results indicate that GW182 modulates PDFR signaling by silencing the expression of the cAMP phosphodiesterase DUNCE. Importantly, this repression is under photic control, and GW182 activity level--which is limiting in circadian neurons--influences the responses of the circadian neural network to light. We propose that GW182's gene silencing activity functions as a rheostat for PDFR signaling and thus profoundly impacts the circadian neural network and its response to environmental inputs.
    Source
    Neuron. 2013 Apr 10;78(1):152-65. doi: 10.1016/j.neuron.2013.01.035. Link to article on publisher's site
    DOI
    10.1016/j.neuron.2013.01.035
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/28758
    PubMed ID
    23583112
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.neuron.2013.01.035
    Scopus Count
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    UMass Chan Faculty and Researcher Publications
    Neurobiology Faculty Publications

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