GBPs take AIM at Francisella
| dc.contributor.author | Fitzgerald, Katherine A. | |
| dc.contributor.author | Rathinam, Vijay A. K. | |
| dc.date | 2022-08-11T08:08:18.000 | |
| dc.date.accessioned | 2022-08-23T15:50:52Z | |
| dc.date.available | 2022-08-23T15:50:52Z | |
| dc.date.issued | 2015-05-01 | |
| dc.date.submitted | 2016-06-15 | |
| dc.identifier.citation | Nat Immunol. 2015 May;16(5):443-4. doi: 10.1038/ni.3144. <a href="http://dx.doi.org/10.1038/ni.3144">Link to article on publisher's site</a> | |
| dc.identifier.issn | 1529-2908 (Linking) | |
| dc.identifier.doi | 10.1038/ni.3144 | |
| dc.identifier.pmid | 25898190 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/28760 | |
| dc.description.abstract | Guanylate-binding proteins (GBPs) induced by type I interferon signaling cause lysis ofFrancisella bacteria that have reached the host-cell cytosol. The liberated bacterial DNA is then sensed by the cytosolic AIM2 inflammasome, which activates caspase-1 and leads to pyroptotic cell death. | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=25898190&dopt=Abstract">Link to Article in PubMed</a> | |
| dc.relation.url | http://dx.doi.org/10.1038/ni.3144 | |
| dc.subject | Immunity | |
| dc.title | GBPs take AIM at Francisella | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Nature immunology | |
| dc.source.volume | 16 | |
| dc.source.issue | 5 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/faculty_pubs/1001 | |
| dc.identifier.contextkey | 8734754 | |
| html.description.abstract | <p>Guanylate-binding proteins (GBPs) induced by type I interferon signaling cause lysis of<em>Francisella</em> bacteria that have reached the host-cell cytosol. The liberated bacterial DNA is then sensed by the cytosolic AIM2 inflammasome, which activates caspase-1 and leads to pyroptotic cell death.</p> | |
| dc.identifier.submissionpath | faculty_pubs/1001 | |
| dc.contributor.department | Department of Medicine, Division of Infectious Diseases and Immunology | |
| dc.contributor.department | Program in Innate Immunity | |
| dc.source.pages | 443-4 |