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    Association between body composition and hip fractures in older women with physical frailty

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    Authors
    Zaslavsky, Oleg
    Li, Wenjun
    Going, Scott
    Datta, Mridul
    Snetselaar, Linda G.
    Zelber-Sagi, Shira
    UMass Chan Affiliations
    UMass Worcester Prevention Research Center
    Department of Medicine, Division of Preventive and Behavioral Medicine
    Document Type
    Journal Article
    Publication Date
    2016-05-10
    Keywords
    bone
    fat mass
    frailty
    hip fracture
    lean mass
    Clinical Epidemiology
    Epidemiology
    Geriatrics
    Women's Health
    
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    Link to Full Text
    https://doi.org/10.1111/ggi.12798
    Abstract
    AIM: We sought to determine the extent to which higher lean and fat mass as measured by dual X-ray absorptiometry in older adults with frailty are related to total hip bone mass density (BMD) index and the rate of hip fractures. METHODS: The data are from the Women's Health Initiative Observational Study. We identified 872 participants aged > /=65 years with body composition measures and positive frailty. Frailty was determined using modified Fried's criteria. Linear and Cox regressions were used to model study outcomes. RESULTS: During the follow-up period, 5.6% patients (n = 49) had sustained a hip fracture. Body composition indexes were associated with total hip BMD (P < 0.001 for all). In models adjusted for age, ethnicity, smoking, history of fractures, recurrent falls, number of frailty criteria and corresponding lean mass, the hazard ratio for hip fracture per 1 kg/m2 increase in fat mass was 0.73 (95% confidence interval 0.60-0.88) for appendicular compartment, 0.76 (95% confidence interval 0.65-0.89) for trunk and 0.84 (95% confidence interval 0.77-0.93) for whole-body fat mass. The hazard ratio for hip fracture per 1 kg/m2 increase in appendicular lean mass was 0.63 (95% confidence interval 0.46-0.88). However, after final adjustment for total hip BMD, the only index that remained statistically significant was whole-body fat mass (P for trend = 0.04). CONCLUSIONS: We showed that in frail older women, higher fat and lean mass was associated with reduced hip-fracture rates. Higher whole-body adiposity, however, was also associated with lower hip-fracture rate independent of total hip BMD. The present results confirm the importance of weight maintenance in frail populations.
    Source
    Geriatr Gerontol Int. 2016 May 10. doi: 10.1111/ggi.12798. Link to article on publisher's site
    DOI
    10.1111/ggi.12798
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/28877
    PubMed ID
    27164296
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1111/ggi.12798
    Scopus Count
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    UMass Chan Faculty and Researcher Publications
    UMass Worcester PRC Publications

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