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dc.contributor.authorRathinam, Vijay A.K.
dc.contributor.authorFitzgerald, Katherine A.
dc.date2022-08-11T08:08:20.000
dc.date.accessioned2022-08-23T15:51:21Z
dc.date.available2022-08-23T15:51:21Z
dc.date.issued2016-05-05
dc.date.submitted2017-02-13
dc.identifier.citationCell. 2016 May 5;165(4):792-800. doi: 10.1016/j.cell.2016.03.046. <a href="https://doi.org/10.1016/j.cell.2016.03.046">Link to article on publisher's site</a>
dc.identifier.issn0092-8674 (Linking)
dc.identifier.doi10.1016/j.cell.2016.03.046
dc.identifier.pmid27153493
dc.identifier.urihttp://hdl.handle.net/20.500.14038/28879
dc.description.abstractCanonical activation of the inflammasome is critical to promote caspase-1-dependent maturation of the proinflammatory cytokines IL-1beta and IL-18, as well as to induce pyroptotic cell death in response to pathogens and endogenous danger signals. Recent discoveries, however, are beginning to unveil new components of the inflammasome machinery as well as the full spectrum of inflammasome functions, extending their influence beyond canonical functions to regulation of eicosanoid storm, autophagy, and metabolism. In addition, the receptor components of the inflammasome can also regulate diverse biological processes, such as cellular proliferation, gene transcription, and tumorigenesis, all of which are independent of their inflammasome complex-forming capabilities. Here, we review these recent advances that are shaping our understanding of the complex biology of the inflammasome and its constituents.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=27153493&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttps://doi.org/10.1016/j.cell.2016.03.046
dc.subjectImmunity
dc.titleInflammasome Complexes: Emerging Mechanisms and Effector Functions
dc.typeJournal Article
dc.source.journaltitleCell
dc.source.volume165
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/1112
dc.identifier.contextkey9679936
html.description.abstract<p>Canonical activation of the inflammasome is critical to promote caspase-1-dependent maturation of the proinflammatory cytokines IL-1beta and IL-18, as well as to induce pyroptotic cell death in response to pathogens and endogenous danger signals. Recent discoveries, however, are beginning to unveil new components of the inflammasome machinery as well as the full spectrum of inflammasome functions, extending their influence beyond canonical functions to regulation of eicosanoid storm, autophagy, and metabolism. In addition, the receptor components of the inflammasome can also regulate diverse biological processes, such as cellular proliferation, gene transcription, and tumorigenesis, all of which are independent of their inflammasome complex-forming capabilities. Here, we review these recent advances that are shaping our understanding of the complex biology of the inflammasome and its constituents.</p>
dc.identifier.submissionpathfaculty_pubs/1112
dc.contributor.departmentDivision of Infectious Diseases and Immunology, Department of Medicine
dc.contributor.departmentProgram in Innate Immunity
dc.source.pages792-800


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