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    The term 'non-radiographic axial spondyloarthritis' is much more important to classify than to diagnose patients with axial spondyloarthritis

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    Authors
    Deodhar, Atul
    Strand, Vibeke
    Kay, Jonathan
    Braun, Juergen
    UMass Chan Affiliations
    Division of Rheumatology, Department of Medicine
    Document Type
    Journal Article
    Publication Date
    2016-05-01
    Keywords
    Ankylosing Spondylitis
    DMARDs (biologic)
    Epidemiology
    Spondyloarthritis
    Treatment
    Musculoskeletal Diseases
    Rheumatology
    
    Metadata
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    Link to Full Text
    https://doi.org/10.1136/annrheumdis-2015-208852
    Abstract
    The term axial spondyloarthritis (axSpA) now is used frequently to describe patients with predominantly axial symptoms who fit into the spectrum of a well-recognised rheumatic disease that continues to be known as ankylosing spondylitis (AS). The 2009 Assessment of SpondyloArthritis international Society (ASAS) classification criteria, developed to identify patients with early or atypical disease which could not be classified by the 1984 modified New York (mNY) criteria for AS, have led to a differentiation between non-radiographic axial spondyloarthritis (nr-axSpA) and radiographic axSpA, which is largely synonymous with AS. The main reason to distinguish between these ends of the spectrum of axSpA was that tumor necrosis factor (TNF) inhibitors (TNFi) approved for AS could obtain additional labelling for nr-axSpA and be used to treat all patients manifesting clinical features of axSpA. These two terms are distinguished by the degree of 'radiographic sacroiliitis' assessed by conventional radiography, according to the 1984 mNY criteria for AS. Since this differentiation has been shown to be not very reliable, we argue that the terms nr-axSpA and AS should only be used for classification of patients with axSpA and not as separate diagnoses. Therefore, we propose that only the term axSpA be used to diagnose patients, unless there is a meaningful medical reason to differentiate nr-axSpA from AS. The available data justify performing randomised controlled trials designed to obtain regulatory approval for therapeutic agents in patients across the entire spectrum of axSpA.
    Source
    Ann Rheum Dis. 2016 May;75(5):791-4. doi: 10.1136/annrheumdis-2015-208852. Epub 2016 Jan 14. Link to article on publisher's site
    DOI
    10.1136/annrheumdis-2015-208852
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/28882
    PubMed ID
    26768406
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1136/annrheumdis-2015-208852
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