Physical Functioning Among Women Aged 80 Years and Older With Previous Fracture
dc.contributor.author | Crandall, Carolyn J. | |
dc.contributor.author | Li, Wenjun | |
dc.date | 2022-08-11T08:08:20.000 | |
dc.date.accessioned | 2022-08-23T15:51:35Z | |
dc.date.available | 2022-08-23T15:51:35Z | |
dc.date.issued | 2016-03-01 | |
dc.date.submitted | 2017-03-07 | |
dc.identifier.citation | J Gerontol A Biol Sci Med Sci. 2016 Mar;71 Suppl 1:S31-41. doi: 10.1093/gerona/glv060. <a href="https://doi.org/10.1093/gerona/glv060">Link to article on publisher's site</a> | |
dc.identifier.issn | 1079-5006 (Linking) | |
dc.identifier.doi | 10.1093/gerona/glv060 | |
dc.identifier.pmid | 26858323 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/28935 | |
dc.description | <p>Full author list omitted for brevity. For full list of authors see article.</p> | |
dc.description.abstract | BACKGROUND: The oldest old are the fastest growing segment of the elderly population. Little is known regarding the associations of fracture history with physical functioning assessed after age 80. METHODS: Among 33,386 women surviving to age 80 years (mean +/- SD years 84.6 +/- 3.4), we examined the relationship between history of incident fracture after entry into the Women's Health Initiative (follow-up 15.2 +/- 1.3 years) and their physical functioning assessed using the RAND-36 instrument most proximal to 2012 end of follow-up. RESULTS: Baseline mean (+/-SD) physical function score was 82 (+/- 18). After adjustment for demographic and medical characteristics, fracture at each site, including hip, upper limb, lower limb, and central body, was associated with significantly lower subsequent physical functioning (all p < .001). Hip, upper leg, spine, and pelvis fractures were particularly related with lower physical functioning scores, 11.7 (95% CI: 10.3, 13.1), 10.5 (8.8, 12.3), 9.8 (8.9, 10.8), and 8.7 (7.2, 10.2) units lower, respectively, compared with women without fracture (each p < .0001). Compared with women without central site fracture, women with central site fractures also had lower physical functioning scores (10.0 [9.3, 10.8] units lower]; p < .0001). In case-only analysis of fractures, older age, less than 1 year since fracture, one or more additional sites fractured, history of cardiovascular disease or cancer, higher body mass index, and no alcohol intake in the past 3 months also were independent predictors of lower physical functioning score (all p < .05). CONCLUSIONS: Among women surviving to 80 years and older, prior fracture is associated with lower current physical functioning, regardless of anatomical site of fracture, independent of other major predictors of disability. | |
dc.language.iso | en_US | |
dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=26858323&dopt=Abstract">Link to Article in PubMed</a> | |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861138/ | |
dc.subject | Fracture | |
dc.subject | Frailty | |
dc.subject | Physical function | |
dc.subject | Geriatrics | |
dc.subject | Women's Health | |
dc.title | Physical Functioning Among Women Aged 80 Years and Older With Previous Fracture | |
dc.type | Journal Article | |
dc.source.journaltitle | The journals of gerontology. Series A, Biological sciences and medical sciences | |
dc.source.volume | 71 Suppl 1 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/faculty_pubs/1163 | |
dc.identifier.contextkey | 9801477 | |
html.description.abstract | <p>BACKGROUND: The oldest old are the fastest growing segment of the elderly population. Little is known regarding the associations of fracture history with physical functioning assessed after age 80.</p> <p>METHODS: Among 33,386 women surviving to age 80 years (mean +/- SD years 84.6 +/- 3.4), we examined the relationship between history of incident fracture after entry into the Women's Health Initiative (follow-up 15.2 +/- 1.3 years) and their physical functioning assessed using the RAND-36 instrument most proximal to 2012 end of follow-up.</p> <p>RESULTS: Baseline mean (+/-SD) physical function score was 82 (+/- 18). After adjustment for demographic and medical characteristics, fracture at each site, including hip, upper limb, lower limb, and central body, was associated with significantly lower subsequent physical functioning (all p < .001). Hip, upper leg, spine, and pelvis fractures were particularly related with lower physical functioning scores, 11.7 (95% CI: 10.3, 13.1), 10.5 (8.8, 12.3), 9.8 (8.9, 10.8), and 8.7 (7.2, 10.2) units lower, respectively, compared with women without fracture (each p < .0001). Compared with women without central site fracture, women with central site fractures also had lower physical functioning scores (10.0 [9.3, 10.8] units lower]; p < .0001). In case-only analysis of fractures, older age, less than 1 year since fracture, one or more additional sites fractured, history of cardiovascular disease or cancer, higher body mass index, and no alcohol intake in the past 3 months also were independent predictors of lower physical functioning score (all p < .05).</p> <p>CONCLUSIONS: Among women surviving to 80 years and older, prior fracture is associated with lower current physical functioning, regardless of anatomical site of fracture, independent of other major predictors of disability.</p> | |
dc.identifier.submissionpath | faculty_pubs/1163 | |
dc.contributor.department | Department of Medicine, Division of Preventive and Behavioral Medicine | |
dc.source.pages | S31-41 |