AuthorsTodd, Derrick J.
UMass Chan AffiliationsDivision of Rheumatology, Department of Medicine
Document TypeJournal Article
chronic kidney disease
gadolinium-based contrast agents
magnetic resonance imaging
nephrogenic systemic fibrosis
Skin and Connective Tissue Diseases
MetadataShow full item record
AbstractGadolinium-based contrast agents (GBCAs), once believed to be safe for patients with renal disease, have been strongly associated with nephrogenic systemic fibrosis (NSF), a severe systemic fibrosing disorder that predominantly afflicts individuals with advanced renal dysfunction. We provide a historical perspective on the appearance and disappearance of NSF, including its initial recognition as a discrete clinical entity, its association with GBCA exposure, and the data supporting a causative relationship between GBCA exposure and NSF. On the basis of this body of evidence, we propose that the name gadolinium-induced fibrosis (GIF) more accurately reflects the totality of knowledge regarding this disease. Use of high-risk GBCAs, such as formulated gadodiamide, should be avoided in patients with renal disease. Restriction of GBCA use in this population has almost completely eradicated new cases of this debilitating condition. Emerging antifibrotic therapies may be useful for patients who suffer from GIF.
SourceAnnu Rev Med. 2016;67:273-91. doi: 10.1146/annurev-med-063014-124936. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/28950
Related ResourcesLink to Article in PubMed