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dc.contributor.authorMatzelle, Melissa M.
dc.contributor.authorShaw, A. T.
dc.contributor.authorBaum, Rebecca
dc.contributor.authorGarrison, Yukiko Maeda
dc.contributor.authorLi, J.
dc.contributor.authorKarmakar, S.
dc.contributor.authorManning, Catherine A.
dc.contributor.authorWalsh, N. C.
dc.contributor.authorRosen, V.
dc.contributor.authorGravallese, Ellen M.
dc.date2022-08-11T08:08:20.000
dc.date.accessioned2022-08-23T15:51:56Z
dc.date.available2022-08-23T15:51:56Z
dc.date.issued2016-10-01
dc.date.submitted2017-05-22
dc.identifier.citation<p>Scand J Rheumatol. 2016 Oct;45(5):379-83 Epub 2016 Mar 16. <a href="https://doi.org/10.3109/03009742.2015.1126347">Link to article on publisher's site</a></p>
dc.identifier.issn0300-9742 (Linking)
dc.identifier.doi10.3109/03009742.2015.1126347
dc.identifier.pmid26982203
dc.identifier.urihttp://hdl.handle.net/20.500.14038/29024
dc.description.abstractOBJECTIVES: Inflammation in diseases such as rheumatoid arthritis (RA) stimulates osteoclast-mediated articular bone erosion and inhibits osteoblast-mediated bone formation, leading to a net loss of bone. Pro-inflammatory cytokines and antagonists of the Wnt signalling pathway have been implicated in the inhibition of osteoblast differentiation and activity in RA, contributing to the erosive process and impairing erosion healing. Importantly, osteoblast differentiation and function are also regulated by the osteogenic bone morphogenetic protein (BMP) signalling pathway, which is antagonized by BMP3. We therefore examined the potential role of BMP3 in inflammatory arthritis. METHOD: Two murine models of RA, K/BxN serum transfer arthritis (STA) and antigen-induced arthritis (AIA), were used to establish the temporal expression of BMP3 and the cellular sources of BMP3 mRNA and protein in inflammatory arthritis. To determine the effects of inflammation on the expression of BMP3 in osteoblasts, murine calvarial osteoblasts were treated with pro-inflammatory cytokines and BMP3 expression was assessed. RESULTS: In both murine models of RA, BMP3 mRNA and protein are highly expressed by osteoblasts lining inflammation-bone interfaces late in the course of arthritis. Synovial tissues are not a significant source of BMP3. BMP3 expression is induced in osteocalcin-expressing osteoblasts in vitro following stimulation by tumour necrosis factor (TNF). CONCLUSIONS: These data implicate BMP3 as a novel factor that may act locally to contribute to the erosive process and inhibit the repair of articular bone in RA through inhibition of osteoblast differentiation and function.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=26982203&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157834/
dc.subjectbone morphogenetic protein (BMP)
dc.subjectosteoblast
dc.subjectrheumatoid arthritis
dc.subjectinflammation
dc.subjectTNF
dc.subjectAmino Acids, Peptides, and Proteins
dc.subjectAnimal Experimentation and Research
dc.subjectBiological Factors
dc.subjectCell Biology
dc.subjectCells
dc.subjectImmune System Diseases
dc.subjectMusculoskeletal Diseases
dc.subjectMusculoskeletal System
dc.subjectPathological Conditions, Signs and Symptoms
dc.subjectRheumatology
dc.subjectSkin and Connective Tissue Diseases
dc.subjectTissues
dc.titleInflammation in arthritis induces expression of BMP3, an inhibitor of bone formation
dc.typeJournal Article
dc.source.journaltitleScandinavian journal of rheumatology
dc.source.volume45
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/1254
dc.identifier.contextkey10195627
html.description.abstract<p>OBJECTIVES: Inflammation in diseases such as rheumatoid arthritis (RA) stimulates osteoclast-mediated articular bone erosion and inhibits osteoblast-mediated bone formation, leading to a net loss of bone. Pro-inflammatory cytokines and antagonists of the Wnt signalling pathway have been implicated in the inhibition of osteoblast differentiation and activity in RA, contributing to the erosive process and impairing erosion healing. Importantly, osteoblast differentiation and function are also regulated by the osteogenic bone morphogenetic protein (BMP) signalling pathway, which is antagonized by BMP3. We therefore examined the potential role of BMP3 in inflammatory arthritis.</p> <p>METHOD: Two murine models of RA, K/BxN serum transfer arthritis (STA) and antigen-induced arthritis (AIA), were used to establish the temporal expression of BMP3 and the cellular sources of BMP3 mRNA and protein in inflammatory arthritis. To determine the effects of inflammation on the expression of BMP3 in osteoblasts, murine calvarial osteoblasts were treated with pro-inflammatory cytokines and BMP3 expression was assessed.</p> <p>RESULTS: In both murine models of RA, BMP3 mRNA and protein are highly expressed by osteoblasts lining inflammation-bone interfaces late in the course of arthritis. Synovial tissues are not a significant source of BMP3. BMP3 expression is induced in osteocalcin-expressing osteoblasts in vitro following stimulation by tumour necrosis factor (TNF).</p> <p>CONCLUSIONS: These data implicate BMP3 as a novel factor that may act locally to contribute to the erosive process and inhibit the repair of articular bone in RA through inhibition of osteoblast differentiation and function.</p>
dc.identifier.submissionpathfaculty_pubs/1254
dc.contributor.departmentDepartment of Cell and Developmental Biology
dc.contributor.departmentDepartment of Medicine, Division of Rheumatology
dc.source.pages379-83


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