Sex hormones in women with and without migraine: Evidence of migraine-specific hormone profiles
Authors
Pavlovic, Jelena M.Allshouse, Amanda A.
Santoro, Nanette F.
Crawford, Sybil L.
Thurston, Rebecca C.
Neal-Perry, Genevieve S.
Lipton, Richard B.
Derby, Carol A.
UMass Chan Affiliations
Department of Medicine, Division of Preventive and Behavioral MedicineDocument Type
Journal ArticlePublication Date
2016-07-05Keywords
Chemical Actions and UsesHormones, Hormone Substitutes, and Hormone Antagonists
Nervous System Diseases
Neurology
Reproductive and Urinary Physiology
Women's Health
Metadata
Show full item recordAbstract
OBJECTIVE: To compare daily sex hormone levels and rates of change between women with history of migraine and controls. METHODS: History of migraine, daily headache diaries, and daily hormone data were collected in ovulatory cycles of pre- and early perimenopausal women in the Study of Women's Health Across the Nation. Peak hormone levels, average daily levels, and within-woman day-to-day rates of decline over the 5 days following each hormone peak were calculated in ovulatory cycles for conjugated urinary estrogens (E1c), pregnanediol-3-glucuronide, luteinizing hormone, and follicle-stimulating hormone. Comparisons were made between migraineurs and controls using 2-sample t tests on the log scale with results reported as geometric means. RESULTS: The sample included 114 women with history of migraine and 223 controls. Analyses of within-woman rates of decline showed that E1c decline over the 2 days following the luteal peak was greater in migraineurs for both absolute rate of decline (33.8 [95% confidence interval 28.0-40.8] pg/mgCr vs 23.1 [95% confidence interval 20.1-26.6] pg/mgCr, p = 0.002) and percent change (40% vs 30%, p < 0.001). There was no significant difference between migraineurs and controls in absolute peak or daily E1c, pregnanediol-3-glucuronide, luteinizing hormone, and follicle-stimulating hormone levels. Secondary analyses demonstrated that, among migraineurs, the rate of E1c decline did not differ according to whether a headache occurred during the cycle studied. CONCLUSIONS: Migraineurs are characterized by faster late luteal phase E1c decline compared to controls. The timing and rate of estrogen withdrawal before menses may be a marker of neuroendocrine vulnerability in women with migraine.Source
Neurology. 2016 Jul 5;87(1):49-56. Epub 2016 Jun 1. Link to article on publisher's site
DOI
10.1212/WNL.0000000000002798Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29031PubMed ID
27251885Related Resources
ae974a485f413a2113503eed53cd6c53
10.1212/WNL.0000000000002798
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