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    Serum brain-derived neurotrophic factor and risk of atrial fibrillation

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    Authors
    Rahman, Faisal
    Himali, Jayandra J.
    Yin, Xiaoyan
    Beiser, Alexa S.
    Ellinor, Patrick T.
    Lubitz, Steven A.
    Vasan, Ramachandran S.
    Magnani, Jared W.
    McManus, David D.
    Seshadri, Sudha
    Benjamin, Emelia J.
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    UMass Chan Affiliations
    Department of Medicine, Division of Cardiovascular Medicine
    Document Type
    Journal Article
    Publication Date
    2017-01-01
    Keywords
    Cardiology
    Cardiovascular Diseases
    
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    Link to Full Text
    https://doi.org/10.1016/j.ahj.2016.07.027
    Abstract
    Brain-derived neurotrophic factor (BDNF) is expressed by endothelial cells and can affect cardiovascular function. We examined if serum BDNF was associated with risk of incident atrial fibrillation (AF) in the Framingham Heart Study. METHODS: We studied individuals without an AF diagnosis at baseline from the Framingham original and offspring cohorts. We used age- and sex-adjusted, and multivariable-adjusted Cox proportional hazards regression models to examine the association of serum BDNF concentrations with 10-year risk of incident AF. RESULTS: We studied 3,457 participants (mean age 65+/-11years, 58% women). During follow-up, 395 participants developed AF. In unadjusted analysis, higher mean serum BDNF concentration was associated with lower incidence of AF (hazard ratio 0.89 per SD, 95% CI 0.80-0.99). In multivariable-adjusted analyses, serum BDNF concentration was not significantly associated with incident AF (hazard ratio 0.98 per SD, 95% CI 0.88-1.09). Compared with the lowest quartile, BDNF levels in the other quartiles were not associated with risk of AF in multivariable-adjusted analyses. No interactions between sex or age with serum BDNF concentrations and risk of AF were found. CONCLUSIONS: In our prospective, community-based sample, we did not find a statistically significant association of serum BDNF levels with risk of incident AF.
    Source
    Am Heart J. 2017 Jan;183:69-73. doi: 10.1016/j.ahj.2016.07.027. Epub 2016 Oct 17. Link to article on publisher's site
    DOI
    10.1016/j.ahj.2016.07.027
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/29042
    PubMed ID
    27979044
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ahj.2016.07.027
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