Serum brain-derived neurotrophic factor and risk of atrial fibrillation
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Authors
Rahman, FaisalHimali, Jayandra J.
Yin, Xiaoyan
Beiser, Alexa S.
Ellinor, Patrick T.
Lubitz, Steven A.
Vasan, Ramachandran S.
Magnani, Jared W.
McManus, David D.
Seshadri, Sudha
Benjamin, Emelia J.
UMass Chan Affiliations
Department of Medicine, Division of Cardiovascular MedicineDocument Type
Journal ArticlePublication Date
2017-01-01
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Brain-derived neurotrophic factor (BDNF) is expressed by endothelial cells and can affect cardiovascular function. We examined if serum BDNF was associated with risk of incident atrial fibrillation (AF) in the Framingham Heart Study. METHODS: We studied individuals without an AF diagnosis at baseline from the Framingham original and offspring cohorts. We used age- and sex-adjusted, and multivariable-adjusted Cox proportional hazards regression models to examine the association of serum BDNF concentrations with 10-year risk of incident AF. RESULTS: We studied 3,457 participants (mean age 65+/-11years, 58% women). During follow-up, 395 participants developed AF. In unadjusted analysis, higher mean serum BDNF concentration was associated with lower incidence of AF (hazard ratio 0.89 per SD, 95% CI 0.80-0.99). In multivariable-adjusted analyses, serum BDNF concentration was not significantly associated with incident AF (hazard ratio 0.98 per SD, 95% CI 0.88-1.09). Compared with the lowest quartile, BDNF levels in the other quartiles were not associated with risk of AF in multivariable-adjusted analyses. No interactions between sex or age with serum BDNF concentrations and risk of AF were found. CONCLUSIONS: In our prospective, community-based sample, we did not find a statistically significant association of serum BDNF levels with risk of incident AF.Source
Am Heart J. 2017 Jan;183:69-73. doi: 10.1016/j.ahj.2016.07.027. Epub 2016 Oct 17. Link to article on publisher's siteDOI
10.1016/j.ahj.2016.07.027Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29042PubMed ID
27979044Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.ahj.2016.07.027