Comparison of control fasting plasma glucose of exercise-only versus exercise-diet among a pre-diabetic population: a meta-analysis
Authors
Zheng, LWu, J
Wang, G
Persuitte, Gioia
Ma, Yunsheng
Zou, L
Zhang, L
Zhao, M
Wang, J
Lan, Qin
Liu, Z
Fan, H
Li, J
UMass Chan Affiliations
Division of Preventive and Behavioral Medicine, Department of MedicineDocument Type
Journal ArticlePublication Date
2016-04-01
Metadata
Show full item recordAbstract
BACKGROUND/OBJECTIVES: Exercise is considered a protective factor in the prevention of type 2 diabetes, although its role as a sole treatment for pre-diabetes remains unknown. The present meta-analysis compared the effect of exercise-only with exercise-diet interventions on plasma glucose levels among a pre-diabetic population. SUBJECTS/METHODS: A literature search was conducted using PubMed, EMBASE and Cochrane databases. The Cochrane Collaboration tool was used to assess the quality of each trial. Two reviewers independently performed quality assessment of all included articles. A random effects model was used to calculate the pooled effect. RESULTS: A total of 4021 participants from 12 studies were included in this meta-analysis, 2045 of them were in the intervention group and 1976 were in the control group. Compared with the exercise-only interventions, the exercise-diet interventions showed a significant effect on decreasing fasting plasma glucose (FPG) levels, with a weighted mean difference (WMD) =-0.22 mmol/l, 95% confidence interval (CI): -0.25, -0.18 (Z=12.06, P 0.05). According to the intervention periods, the pooled effect in the 2-year group was the highest, and its WMD (95% CI) was -0.24 mmol/l (-0.43,-0.05). The pooled effects were statistically significant among the elderly and those of American and European descent, with WMD (95% CI) being -0.19 mmol/l (95% CI: -0.22, -0.15), -0.17 mmol/l (-0.21,-0.12) and -0.22 mmol/l (-0.27, -0.17), respectively. CONCLUSIONS: Evidence from published trials indicates that exercise-diet interventions showed a significant effect on decreasing FPG levels.Source
Eur J Clin Nutr. 2016 Apr;70(4):424-30. doi: 10.1038/ejcn.2015.128. Epub 2015 Sep 2. Link to article on publisher's siteDOI
10.1038/ejcn.2015.128Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29066PubMed ID
26330149Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/ejcn.2015.128