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dc.contributor.authorCauley, Jane A.
dc.contributor.authorSmagula, Stephen F.
dc.contributor.authorHovey, Kathleen M.
dc.contributor.authorWactawski-Wende, Jean
dc.contributor.authorAndrews, Christopher A.
dc.contributor.authorCrandall, Carolyn J.
dc.contributor.authorLeBoff, Meryl S.
dc.contributor.authorLi, Wenjun
dc.contributor.authorCoday, Mace
dc.contributor.authorSattari, Maryam
dc.contributor.authorTindle, Hilary A.
dc.date2022-08-11T08:08:21.000
dc.date.accessioned2022-08-23T15:52:12Z
dc.date.available2022-08-23T15:52:12Z
dc.date.issued2017-02-01
dc.date.submitted2017-06-14
dc.identifier.citationJ Bone Miner Res. 2017 Feb;32(2):221-229. Epub 2016 Sep 20. <a href="https://doi.org/10.1002/jbmr.2984">Link to article on publisher's site</a>
dc.identifier.issn0884-0431 (Linking)
dc.identifier.doi10.1002/jbmr.2984
dc.identifier.pmid27566996
dc.identifier.urihttp://hdl.handle.net/20.500.14038/29084
dc.description.abstractTraits of optimism and cynical hostility are features of personality that could influence the risk of falls and fractures by influencing risk-taking behaviors, health behaviors, or inflammation. To test the hypothesis that personality influences falls and fracture risk, we studied 87,342 women enrolled in WHI-OS. Optimism was assessed by the Life Orientation Test-Revised and cynical hostility, the cynicism subscale of the Cook-Medley questionnaire. Higher scores indicate greater optimism and hostility. Optimism and hostility were correlated at r = -0. 31, p < 0.001. Annual self-report of falling > /=2 times in the past year was modeled using repeated measures logistic regression. Cox proportional hazards models were used for the fracture outcomes. We examined the risk of falls and fractures across the quartiles (Q) of optimism and hostility with tests for trends; Q1 formed the referent group. The average follow-up for fractures was 11.4 years and for falls was 7.6 years. In multivariable (MV)-adjusted models, women with the highest optimism scores (Q4) were 11% less likely to report > /=2 falls in the past year (odds ratio [OR] = 0.89; 95% confidence intervals [CI] 0.85-0.90). Women in Q4 for hostility had a 12% higher risk of > /=2 falls (OR = 1.12; 95% CI 1.07-1.17). Higher optimism scores were also associated with a 10% lower risk of fractures, but this association was attenuated in MV models. Women with the greatest hostility (Q4) had a modest increased risk of any fracture (MV-adjusted hazard ratio = 1. 05; 95% CI 1.01-1.09), but there was no association with specific fracture sites. In conclusion, optimism was independently associated with a decreased risk of > /=2 falls, and hostility with an increased risk of > /=2 falls, independent of traditional risk factors. The magnitude of the association was similar to aging 5 years. Whether interventions aimed at attitudes could reduce fall risks remains to be determined.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=27566996&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttps://doi.org/10.1002/jbmr.2984
dc.subjectFALLS
dc.subjectFRACTURES
dc.subjectHOSTILITY
dc.subjectOPTIMISM
dc.subjectPERSONALITY
dc.subjectPROSPECTIVE STUDY
dc.subjectWOMEN'S HEALTH INITIATIVE
dc.subjectMusculoskeletal Diseases
dc.subjectPsychiatry and Psychology
dc.subjectWomen's Health
dc.titleOptimism, Cynical Hostility, Falls, and Fractures: The Women's Health Initiative Observational Study (WHI-OS)
dc.typeJournal Article
dc.source.journaltitleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
dc.source.volume32
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/1311
dc.identifier.contextkey10302856
html.description.abstract<p>Traits of optimism and cynical hostility are features of personality that could influence the risk of falls and fractures by influencing risk-taking behaviors, health behaviors, or inflammation. To test the hypothesis that personality influences falls and fracture risk, we studied 87,342 women enrolled in WHI-OS. Optimism was assessed by the Life Orientation Test-Revised and cynical hostility, the cynicism subscale of the Cook-Medley questionnaire. Higher scores indicate greater optimism and hostility. Optimism and hostility were correlated at r = -0. 31, p < 0.001. Annual self-report of falling > /=2 times in the past year was modeled using repeated measures logistic regression. Cox proportional hazards models were used for the fracture outcomes. We examined the risk of falls and fractures across the quartiles (Q) of optimism and hostility with tests for trends; Q1 formed the referent group. The average follow-up for fractures was 11.4 years and for falls was 7.6 years. In multivariable (MV)-adjusted models, women with the highest optimism scores (Q4) were 11% less likely to report > /=2 falls in the past year (odds ratio [OR] = 0.89; 95% confidence intervals [CI] 0.85-0.90). Women in Q4 for hostility had a 12% higher risk of > /=2 falls (OR = 1.12; 95% CI 1.07-1.17). Higher optimism scores were also associated with a 10% lower risk of fractures, but this association was attenuated in MV models. Women with the greatest hostility (Q4) had a modest increased risk of any fracture (MV-adjusted hazard ratio = 1. 05; 95% CI 1.01-1.09), but there was no association with specific fracture sites. In conclusion, optimism was independently associated with a decreased risk of > /=2 falls, and hostility with an increased risk of > /=2 falls, independent of traditional risk factors. The magnitude of the association was similar to aging 5 years. Whether interventions aimed at attitudes could reduce fall risks remains to be determined.</p>
dc.identifier.submissionpathfaculty_pubs/1311
dc.contributor.departmentPrevention Research Center
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine
dc.source.pages221-229


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