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    Dietary Inflammatory Index, Bone Mineral Density, and Risk of Fracture in Postmenopausal Women: Results From the Women's Health Initiative

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    Authors
    Orchard, Tonya
    Yildiz, Vedat
    Steck, Susan E.
    Ma, Yunsheng
    Cauley, Jane A.
    Li, Wenjun
    Mossavar-Rahmani, Yasmin
    Johnson, Karen C.
    Sattari, Maryam
    LeBoff, Meryl
    Wactawski-Wende, Jean
    Jackson, Rebecca D.
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    UMass Chan Affiliations
    Division of Preventive and Behavioral Medicine, Department of Medicine
    Document Type
    Journal Article
    Publication Date
    2017-05-01
    Keywords
    EPIDEMIOLOGY
    FRACTURE RISK ASSESSMENT
    MENOPAUSE
    NUTRITION
    OSTEOPOROSIS
    Dietetics and Clinical Nutrition
    Musculoskeletal Diseases
    Women's Health
    
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    Link to Full Text
    https://doi.org/10.1002/jbmr.3070
    Abstract
    Previous studies suggest that bone loss and fracture risk are associated with higher inflammatory milieu, potentially modifiable by diet. The primary objective of this analysis was to evaluate the association of the dietary inflammatory index (DII), a measure of the inflammatory potential of diet, with risk of hip, lower-arm, and total fracture using longitudinal data from the Women's Health Initiative Observational Study and Clinical Trials. Secondarily, we evaluated changes in bone mineral density (BMD) and DII scores. DII scores were calculated from baseline food frequency questionnaires (FFQs) completed by 160,191 participants (mean age 63 years) without history of hip fracture at enrollment. Year 3 FFQs were used to calculate a DII change score. Fractures were reported at least annually; hip fractures were confirmed by medical records. Hazard ratios for fractures were computed using multivariable-adjusted Cox proportional hazard models, further stratified by age and race/ethnicity. Pairwise comparisons of changes in hip BMD, measured by dual-energy X-ray absorptiometry from baseline, year 3, and year 6 were analyzed by quartile (Q1 = least inflammatory diet) of baseline DII scores in a subgroup of women (n = 10,290). Mean DII score improved significantly over 3 years (p < 0.01), but change was not associated with fracture risk. Baseline DII score was only associated with hip fracture risk in younger white women (HR Q4,1.48; 95% CI, 1.09 to 2.01; p = 0.01). There were no significant associations among white women older than 63 years or other races/ethnicities. Women with the least inflammatory DII scores had less loss of hip BMD (p = 0.01) by year 6, despite lower baseline hip BMD, versus women with the most inflammatory DII scores. In conclusion, a less inflammatory dietary pattern was associated with less BMD loss in postmenopausal women. A more inflammatory diet was associated with increased hip fracture risk only in white women younger than 63 years.
    Source
    J Bone Miner Res. 2017 May;32(5):1136-1146. Epub 2017 Feb 21. Link to article on publisher's site
    DOI
    10.1002/jbmr.3070
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/29085
    PubMed ID
    28019686
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/jbmr.3070
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