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dc.contributor.authorOrchard, Tonya
dc.contributor.authorYildiz, Vedat
dc.contributor.authorSteck, Susan E.
dc.contributor.authorMa, Yunsheng
dc.contributor.authorCauley, Jane A.
dc.contributor.authorLi, Wenjun
dc.contributor.authorMossavar-Rahmani, Yasmin
dc.contributor.authorJohnson, Karen C.
dc.contributor.authorSattari, Maryam
dc.contributor.authorLeBoff, Meryl
dc.contributor.authorWactawski-Wende, Jean
dc.contributor.authorJackson, Rebecca D.
dc.date2022-08-11T08:08:21.000
dc.date.accessioned2022-08-23T15:52:12Z
dc.date.available2022-08-23T15:52:12Z
dc.date.issued2017-05-01
dc.date.submitted2017-06-14
dc.identifier.citationJ Bone Miner Res. 2017 May;32(5):1136-1146. Epub 2017 Feb 21. <a href="https://doi.org/10.1002/jbmr.3070">Link to article on publisher's site</a>
dc.identifier.issn0884-0431 (Linking)
dc.identifier.doi10.1002/jbmr.3070
dc.identifier.pmid28019686
dc.identifier.urihttp://hdl.handle.net/20.500.14038/29085
dc.description.abstractPrevious studies suggest that bone loss and fracture risk are associated with higher inflammatory milieu, potentially modifiable by diet. The primary objective of this analysis was to evaluate the association of the dietary inflammatory index (DII), a measure of the inflammatory potential of diet, with risk of hip, lower-arm, and total fracture using longitudinal data from the Women's Health Initiative Observational Study and Clinical Trials. Secondarily, we evaluated changes in bone mineral density (BMD) and DII scores. DII scores were calculated from baseline food frequency questionnaires (FFQs) completed by 160,191 participants (mean age 63 years) without history of hip fracture at enrollment. Year 3 FFQs were used to calculate a DII change score. Fractures were reported at least annually; hip fractures were confirmed by medical records. Hazard ratios for fractures were computed using multivariable-adjusted Cox proportional hazard models, further stratified by age and race/ethnicity. Pairwise comparisons of changes in hip BMD, measured by dual-energy X-ray absorptiometry from baseline, year 3, and year 6 were analyzed by quartile (Q1 = least inflammatory diet) of baseline DII scores in a subgroup of women (n = 10,290). Mean DII score improved significantly over 3 years (p < 0.01), but change was not associated with fracture risk. Baseline DII score was only associated with hip fracture risk in younger white women (HR Q4,1.48; 95% CI, 1.09 to 2.01; p = 0.01). There were no significant associations among white women older than 63 years or other races/ethnicities. Women with the least inflammatory DII scores had less loss of hip BMD (p = 0.01) by year 6, despite lower baseline hip BMD, versus women with the most inflammatory DII scores. In conclusion, a less inflammatory dietary pattern was associated with less BMD loss in postmenopausal women. A more inflammatory diet was associated with increased hip fracture risk only in white women younger than 63 years.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=28019686&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttps://doi.org/10.1002/jbmr.3070
dc.subjectEPIDEMIOLOGY
dc.subjectFRACTURE RISK ASSESSMENT
dc.subjectMENOPAUSE
dc.subjectNUTRITION
dc.subjectOSTEOPOROSIS
dc.subjectDietetics and Clinical Nutrition
dc.subjectMusculoskeletal Diseases
dc.subjectWomen's Health
dc.titleDietary Inflammatory Index, Bone Mineral Density, and Risk of Fracture in Postmenopausal Women: Results From the Women's Health Initiative
dc.typeJournal Article
dc.source.journaltitleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
dc.source.volume32
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/1312
dc.identifier.contextkey10302861
html.description.abstract<p>Previous studies suggest that bone loss and fracture risk are associated with higher inflammatory milieu, potentially modifiable by diet. The primary objective of this analysis was to evaluate the association of the dietary inflammatory index (DII), a measure of the inflammatory potential of diet, with risk of hip, lower-arm, and total fracture using longitudinal data from the Women's Health Initiative Observational Study and Clinical Trials. Secondarily, we evaluated changes in bone mineral density (BMD) and DII scores. DII scores were calculated from baseline food frequency questionnaires (FFQs) completed by 160,191 participants (mean age 63 years) without history of hip fracture at enrollment. Year 3 FFQs were used to calculate a DII change score. Fractures were reported at least annually; hip fractures were confirmed by medical records. Hazard ratios for fractures were computed using multivariable-adjusted Cox proportional hazard models, further stratified by age and race/ethnicity. Pairwise comparisons of changes in hip BMD, measured by dual-energy X-ray absorptiometry from baseline, year 3, and year 6 were analyzed by quartile (Q1 = least inflammatory diet) of baseline DII scores in a subgroup of women (n = 10,290). Mean DII score improved significantly over 3 years (p < 0.01), but change was not associated with fracture risk. Baseline DII score was only associated with hip fracture risk in younger white women (HR Q4,1.48; 95% CI, 1.09 to 2.01; p = 0.01). There were no significant associations among white women older than 63 years or other races/ethnicities. Women with the least inflammatory DII scores had less loss of hip BMD (p = 0.01) by year 6, despite lower baseline hip BMD, versus women with the most inflammatory DII scores. In conclusion, a less inflammatory dietary pattern was associated with less BMD loss in postmenopausal women. A more inflammatory diet was associated with increased hip fracture risk only in white women younger than 63 years.</p>
dc.identifier.submissionpathfaculty_pubs/1312
dc.contributor.departmentDivision of Preventive and Behavioral Medicine, Department of Medicine
dc.source.pages1136-1146


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