Calcium plus vitamin D supplementation and height loss: findings from the Women's Health Initiative Calcium and Vitamin D clinical trial
Authors
Crandall, Carolyn J.Aragaki, Aaron K.
LeBoff, Meryl S.
Li, Wenjun
Wactawski-Wende, Jean
Cauley, Jane A.
Margolis, Karen L.
Manson, JoAnn E.
UMass Chan Affiliations
Department of Medicine, Division of Preventive and Behavioral MedicineDocument Type
Journal ArticlePublication Date
2016-12-01Keywords
CalciumHeight loss
Vitamin D
Women’s Health Initiative
Biological Factors
Inorganic Chemicals
Polycyclic Compounds
Therapeutics
Women's Health
Metadata
Show full item recordAbstract
OBJECTIVE: The aim of this study was to determine the associations between calcium + vitamin D supplementation (vs placebo) and height loss in 36,282 participants of the Women's Health Initiative Calcium and Vitamin D trial. METHODS: Post hoc analysis of data from a double-blind randomized controlled trial of 1,000 mg of elemental calcium as calcium carbonate with 400 IU of vitamin D3 daily (CaD) or placebo in postmenopausal women at 40 US clinical centers. Height was measured annually (mean follow-up 5.9 y) with a stadiometer. RESULTS: Average height loss was 1.28 mm/y among participants assigned to CaD versus 1.26 mm/y for women assigned to placebo (P = 0.35). Effect modification of the CaD intervention was not observed by age, race/ethnicity, or baseline intake of calcium or vitamin D. Randomization to the CaD group did not reduce the risk of clinical height loss (loss of > /=1.5 inches [3.8 cm]: hazard ratio (95% CI) = 1.00 (0.81, 1.23). A strong association (P < 0.001) was observed between age group and height loss. When we censored follow-up data in participants who became nonadherent to study pills, the results were similar to those of our primary analysis. CONCLUSIONS: Compared with placebo, the CaD supplement used in this trial did not prevent height loss in healthy postmenopausal women.Source
Menopause. 2016 Dec;23(12):1277-1286. Link to article on publisher's site
DOI
10.1097/GME.0000000000000704Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29125PubMed ID
27483038Related Resources
ae974a485f413a2113503eed53cd6c53
10.1097/GME.0000000000000704