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dc.contributor.authorSchiel, John
dc.contributor.authorChilds, Carly
dc.contributor.authorPrekeris, Rytis
dc.date2022-08-11T08:08:22.000
dc.date.accessioned2022-08-23T15:52:25Z
dc.date.available2022-08-23T15:52:25Z
dc.date.issued2013-07-01
dc.date.submitted2013-07-08
dc.identifier.citationTrends Cell Biol. 2013 Jul;23(7):319-27. doi: 10.1016/j.tcb.2013.02.003. <a href="http://dx.doi.org/10.1016/j.tcb.2013.02.003">Link to article on publisher's site</a>
dc.identifier.issn0962-8924 (Linking)
dc.identifier.doi10.1016/j.tcb.2013.02.003
dc.identifier.pmid23522622
dc.identifier.urihttp://hdl.handle.net/20.500.14038/29134
dc.description.abstractAbscission is the last step of cytokinesis that leads to the physical separation of two daughter cells. An emerging picture is that abscission is a complex event that relies on changes in both lipid composition and cytoskeletal dynamics. These subcellular processes lead to the establishment of the abscission site and recruitment of the ESCRT-III protein complex to mediate the final separation event. It has become apparent that endocytic transport to the cleavage furrow during late cytokinesis mediates and coordinates lipid and cytoskeleton dynamics, thus playing a key role in abscission. Furthermore, new evidence suggests that endosomes may have additional roles in post-mitotic cellular events such as midbody inheritance and degradation. Here, we highlight recent findings regarding the function of these endosomes in the regulation of cell division.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23522622&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.tcb.2013.02.003
dc.subjectendosome
dc.subjectphosphoinositide
dc.subjectRho kinase
dc.subjectESCRT-III complex
dc.subjectCell Biology
dc.titleEndocytic transport and cytokinesis: from regulation of the cytoskeleton to midbody inheritance
dc.typeJournal Article
dc.source.journaltitleTrends in cell biology
dc.source.volume23
dc.source.issue7
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/136
dc.identifier.contextkey4295155
html.description.abstract<p>Abscission is the last step of cytokinesis that leads to the physical separation of two daughter cells. An emerging picture is that abscission is a complex event that relies on changes in both lipid composition and cytoskeletal dynamics. These subcellular processes lead to the establishment of the abscission site and recruitment of the ESCRT-III protein complex to mediate the final separation event. It has become apparent that endocytic transport to the cleavage furrow during late cytokinesis mediates and coordinates lipid and cytoskeleton dynamics, thus playing a key role in abscission. Furthermore, new evidence suggests that endosomes may have additional roles in post-mitotic cellular events such as midbody inheritance and degradation. Here, we highlight recent findings regarding the function of these endosomes in the regulation of cell division.</p>
dc.identifier.submissionpathfaculty_pubs/136
dc.contributor.departmentProgram in Molecular Medicine
dc.source.pages319-27


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