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    Does EBV alter the pathogenesis of malaria

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    Authors
    Matar, C. G.
    Jacobs, N. T.
    Speck, S. H.
    Lamb, T. J.
    Moormann, Ann M.
    UMass Chan Affiliations
    Program in Molecular Medicine
    Document Type
    Journal Article
    Publication Date
    2015-09-01
    Keywords
    animal models
    co‐infection
    epidemiologic studies
    immunity
    Animal Experimentation and Research
    Epidemiology
    Hemic and Immune Systems
    Immunopathology
    Parasitic Diseases
    Parasitology
    Pathology
    Viruses
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    Link to Full Text
    https://doi.org/10.1111/pim.12212
    Abstract
    Plasmodium falciparum infections have been implicated in immune deficiencies resulting in ineffective control of Epstein-Barr virus, thereby increasing the risk of endemic Burkitt lymphoma in children. However, the impact of Epstein-Barr virus infections on the development of immunity to P. falciparum has not been studied in depth. In this review, we examine novel findings from animal co-infection models and human immuno-epidemiologic studies to speculate on the impact of acute gammaherpesvirus co-infection on malarial disease severity. Children are often concurrently or sequentially infected with multiple pathogens, and this has implications for understanding the development of protective immunity as well as in the evaluation of vaccine efficacy.
    Source

    Parasite Immunol. 2015 Sep;37(9):433-45. doi: 10.1111/pim.12212. Link to article on publisher's site

    DOI
    10.1111/pim.12212
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/29135
    PubMed ID
    26121587
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1111/pim.12212
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