Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus
UMass Chan Affiliations
Department of Medicine, Division of Preventive and Behavioral MedicineDocument Type
Journal ArticlePublication Date
2016-09-02
Metadata
Show full item recordAbstract
HIV-1-specific broadly neutralizing antibodies (bNAbs) can protect rhesus monkeys against simian-human immunodeficiency virus (SHIV) challenge. However, the site of antibody interception of virus and the mechanism of antibody-mediated protection remain unclear. We administered a fully protective dose of the bNAb PGT121 to rhesus monkeys and challenged them intravaginally with SHIV-SF162P3. In PGT121-treated animals, we detected low levels of viral RNA and viral DNA in distal tissues for seven days following challenge. Viral RNA-positive tissues showed transcriptomic changes indicative of innate immune activation, and cells from these tissues initiated infection after adoptive transfer into naive hosts. These data demonstrate that bNAb-mediated protection against a mucosal virus challenge can involve clearance of infectious virus in distal tissues.Source
Science. 2016 Sep 2;353(6303):1045-1049. Epub 2016 Aug 18. Link to article on publisher's siteDOI
10.1126/science.aag0491Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29144PubMed ID
27540005Notes
Full list of authors omitted for brevity. For full list see article.
Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1126/science.aag0491