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    Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus

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    Authors
    Liu, Jinyan
    Li, Wenjun
    Barouch, Dan H.
    UMass Chan Affiliations
    Department of Medicine, Division of Preventive and Behavioral Medicine
    Document Type
    Journal Article
    Publication Date
    2016-09-02
    Keywords
    Immunology and Infectious Disease
    Virus Diseases
    
    Metadata
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237379/
    Abstract
    HIV-1-specific broadly neutralizing antibodies (bNAbs) can protect rhesus monkeys against simian-human immunodeficiency virus (SHIV) challenge. However, the site of antibody interception of virus and the mechanism of antibody-mediated protection remain unclear. We administered a fully protective dose of the bNAb PGT121 to rhesus monkeys and challenged them intravaginally with SHIV-SF162P3. In PGT121-treated animals, we detected low levels of viral RNA and viral DNA in distal tissues for seven days following challenge. Viral RNA-positive tissues showed transcriptomic changes indicative of innate immune activation, and cells from these tissues initiated infection after adoptive transfer into naive hosts. These data demonstrate that bNAb-mediated protection against a mucosal virus challenge can involve clearance of infectious virus in distal tissues.
    Source
    Science. 2016 Sep 2;353(6303):1045-1049. Epub 2016 Aug 18. Link to article on publisher's site
    DOI
    10.1126/science.aag0491
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/29144
    PubMed ID
    27540005
    Notes

    Full list of authors omitted for brevity. For full list see article.

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    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1126/science.aag0491
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