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Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus

dc.contributor.authorLiu, Jinyan
dc.contributor.authorLi, Wenjun
dc.contributor.authorBarouch, Dan H.
dc.date2022-08-11T08:08:22.000
dc.date.accessioned2022-08-23T15:52:28Z
dc.date.available2022-08-23T15:52:28Z
dc.date.issued2016-09-02
dc.date.submitted2017-06-30
dc.identifier.citationScience. 2016 Sep 2;353(6303):1045-1049. Epub 2016 Aug 18. <a href="https://doi.org/10.1126/science.aag0491">Link to article on publisher's site</a>
dc.identifier.issn0036-8075 (Linking)
dc.identifier.doi10.1126/science.aag0491
dc.identifier.pmid27540005
dc.identifier.urihttp://hdl.handle.net/20.500.14038/29144
dc.description<p>Full list of authors omitted for brevity. For full list see article.</p>
dc.description.abstractHIV-1-specific broadly neutralizing antibodies (bNAbs) can protect rhesus monkeys against simian-human immunodeficiency virus (SHIV) challenge. However, the site of antibody interception of virus and the mechanism of antibody-mediated protection remain unclear. We administered a fully protective dose of the bNAb PGT121 to rhesus monkeys and challenged them intravaginally with SHIV-SF162P3. In PGT121-treated animals, we detected low levels of viral RNA and viral DNA in distal tissues for seven days following challenge. Viral RNA-positive tissues showed transcriptomic changes indicative of innate immune activation, and cells from these tissues initiated infection after adoptive transfer into naive hosts. These data demonstrate that bNAb-mediated protection against a mucosal virus challenge can involve clearance of infectious virus in distal tissues.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=27540005&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237379/
dc.subjectImmunology and Infectious Disease
dc.subjectVirus Diseases
dc.titleAntibody-mediated protection against SHIV challenge includes systemic clearance of distal virus
dc.typeJournal Article
dc.source.journaltitleScience (New York, N.Y.)
dc.source.volume353
dc.source.issue6303
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/1372
dc.identifier.contextkey10382281
html.description.abstract<p>HIV-1-specific broadly neutralizing antibodies (bNAbs) can protect rhesus monkeys against simian-human immunodeficiency virus (SHIV) challenge. However, the site of antibody interception of virus and the mechanism of antibody-mediated protection remain unclear. We administered a fully protective dose of the bNAb PGT121 to rhesus monkeys and challenged them intravaginally with SHIV-SF162P3. In PGT121-treated animals, we detected low levels of viral RNA and viral DNA in distal tissues for seven days following challenge. Viral RNA-positive tissues showed transcriptomic changes indicative of innate immune activation, and cells from these tissues initiated infection after adoptive transfer into naive hosts. These data demonstrate that bNAb-mediated protection against a mucosal virus challenge can involve clearance of infectious virus in distal tissues.</p>
dc.identifier.submissionpathfaculty_pubs/1372
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine
dc.source.pages1045-1049


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