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    Cooperative effects of drug-resistance mutations in the flap region of HIV-1 protease

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    Authors
    Foulkes-Murzycki, Jennifer E.
    Rosi, Christina
    Yilmaz, Nese Kurt
    Shafer, Robert W.
    Schiffer, Celia A.
    UMass Chan Affiliations
    Department of Biochemistry and Molecular Pharmacology
    Document Type
    Journal Article
    Publication Date
    2013-03-15
    Keywords
    HIV Protease
    HIV-1
    Drug Resistance, Viral
    Biochemistry
    Microbial Physiology
    Virus Diseases
    
    Metadata
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    Link to Full Text
    http://dx.doi.org/10.1021/cb3006193
    Abstract
    Understanding the interdependence of multiple mutations in conferring drug resistance is crucial to the development of novel and robust inhibitors. As HIV-1 protease continues to adapt and evade inhibitors while still maintaining the ability to specifically recognize and efficiently cleave its substrates, the problem of drug resistance has become more complicated. Under the selective pressure of therapy, correlated mutations accumulate throughout the enzyme to compromise inhibitor binding, but characterizing their energetic interdependency is not straightforward. A particular drug resistant variant (L10I/G48V/I54V/V82A) displays extreme entropy-enthalpy compensation relative to wild-type enzyme but a similar variant (L10I/G48V/I54A/V82A) does not. Individual mutations of sites in the flaps (residues 48 and 54) of the enzyme reveal that the thermodynamic effects are not additive. Rather, the thermodynamic profile of the variants is interdependent on the cooperative effects exerted by a particular combination of mutations simultaneously present.
    Source
    ACS Chem Biol. 2013 Mar 15;8(3):513-8. doi: 10.1021/cb3006193. Epub 2012 Dec 27. Link to article on publisher's site
    DOI
    10.1021/cb3006193
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/29152
    PubMed ID
    23252515
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1021/cb3006193
    Scopus Count
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    UMass Chan Faculty and Researcher Publications
    Schiffer Lab Publications

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