Semen Quality Parameters Among U.S. Veterans of Operation Enduring Freedom, Operation Iraqi Freedom, and Operation New Dawn

Abstract

BACKGROUND: There is little research investigating exposures that occurred during war or conflict and the resulting influence on semen quality. We examined the associations between military service and semen quality among U.S. Veterans of Operation Enduring Freedom, Operation Iraqi Freedom, and Operational New Dawn. METHODS: U.S. Veterans (n = 714), who sought fertility treatment and were participants of the Department of Veterans Affairs Women Veterans Cohort Study were included in the current study. Semen quality parameters (semen volume, total sperm count, sperm concentration, and percentage of total motile sperm) measured at fertility clinics in Veterans Affairs Healthcare System were analyzed. FINDINGS: The median values of Veterans were 2.7 mL for semen volume, 55.3 x 10(6) for total sperm count, 22.0 x 10(6)/mL for sperm concentration, and 55% for total motile sperm. No significant differences among Veterans were found between military-specific variables evaluated and sperm quality. In multivariate models, Veterans > /=46 years of age had lower semen volume (beta = -0.10 +/- 0.05; p < 0.05) and lower percent total motile sperm (beta = -18.45 +/- 7.0; p = 0.009) than Veterans 18 to 25 years of age. Black and Hispanic Veterans had lower sperm concentrations as compared to White Veterans (beta = -0.17 +/- 0.07; p = 0.01 and beta = -0.20 +/- 0.06; p < 0.001, respectively). Finally, Veterans diagnosed with post-traumatic stress disorder or major depression had lower total sperm motility (beta = -0.10 +/- 0.03; p = 0.004 and beta = -0.09 +/- 0.04; p < 0.05, respectively). DISCUSSION: Veterans who were older, Hispanic or Black, or diagnosed with post-traumatic stress disorder or major depression were more likely to have lower sperm quality. Longitudinal studies are needed to better characterize the influence of military-specific exposures on semen quality parameters.