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    BK channels mediate dopamine inhibition of firing in a subpopulation of core nucleus accumbens medium spiny neurons

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    Authors
    Ji, Xincai
    Martin, Gilles E.
    UMass Chan Affiliations
    Martin Lab
    The Brudnick Neuropsychiatric Research Institute
    Department of Psychiatry
    Document Type
    Journal Article
    Publication Date
    2014-11-07
    Keywords
    BK channels
    Dopamine
    Mice
    Nucleus accumbens
    Potassium channels
    Neuroscience and Neurobiology
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252357/
    Abstract
    Dopamine, a key neurotransmitter mediating the rewarding properties of drugs of abuse, is widely believed to exert some of its effects by modulating neuronal activity of nucleus accumbens (NAcc) medium spiny neurons (MSNs). Although its effects on synaptic transmission have been well documented, its regulation of intrinsic neuronal excitability is less understood. In this study, we examined the cellular mechanisms of acute dopamine effects on core accumbens MSNs evoked firing. We found that 0.5 microM A-77636 and 10 microM quinpirole, dopamine D1 (DR1s) and D2 receptor (D2Rs) agonists, respectively, markedly inhibited MSN evoked action potentials. This effect, observed only in about 25% of all neurons, was associated with spike-timing-dependent (STDP) long-term potentiation (tLTP), but not long-term depression (tLTD). Dopamine inhibits evoked firing by compromising subthreshold depolarization, not by altering action potentials themselves. Recordings in voltage-clamp mode revealed that all MSNs expressed fast (IA), slowly inactivating delayed rectifier (Idr), and large conductance voltage- and calcium-activated potassium (BKs) channels. Although A-77636 and quinpirole enhanced IA, its selective blockade by 0.5 microM phrixotoxin-1 had no effect on evoked firing. In contrast, exposing tissue to low TEA concentrations and to 10 microM paxilline, a selective BK channel blocker, prevented D1R agonist from inhibiting MSN firing. This result indicates that dopamine inhibits MSN firing through BK channels in a subpopulation of core accumbens MSNs exclusively associated with spike-timing-dependent long-term potentiation.
    Source

    Brain Res. 2014 Nov 7;1588:1-16. doi: 10.1016/j.brainres.2014.09.015. Epub 2014 Sep 16. Link to article on publisher's site

    DOI
    10.1016/j.brainres.2014.09.015
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/29219
    PubMed ID
    25219484
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1016/j.brainres.2014.09.015
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