Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data [preprint]
UMass Chan Affiliations
Department of Quantitative Health SciencesDocument Type
PreprintPublication Date
2018-03-10Keywords
bioinformaticspsychiatric disorders
single nucleotide polymorphisms
SNPs
genome-wide association studies
GWASs
immune-related disorders
linkage disequilibrium score regression
LDSC
Bioinformatics
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Genetic Phenomena
Genetics and Genomics
Immune System Diseases
Mental Disorders
Population Biology
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Show full item recordAbstract
Individuals with psychiatric disorders have elevated rates of autoimmune comorbidity and altered immune signaling. It is unclear whether these altered immunological states have a shared genetic basis with those psychiatric disorders. The present study sought to use existing summary-level data from previous genome-wide association studies (GWASs) to determine if commonly varying single nucleotide polymorphisms (SNPs) are shared between psychiatric and immune-related phenotypes. We estimated heritability and examined pair-wise genetic correlations using the linkage disequilibrium score regression (LDSC) and heritability estimation from summary statistics (HESS) methods. Using LDSC, we observed significant genetic correlations between immune-related disorders and several psychiatric disorders, including anorexia nervosa, attention deficit-hyperactivity disorder, bipolar disorder, major depression, obsessive compulsive disorder, schizophrenia, smoking behavior, and Tourette syndrome. Loci significantly mediating genetic correlations were identified for schizophrenia when analytically paired with Crohns disease, primary biliary cirrhosis, systemic lupus erythematosus, and ulcerative colitis. We report significantly correlated loci and highlight those containing genome-wide associations and candidate genes for respective disorders. We also used the LDSC method to characterize genetic correlations amongst the immune-related phenotypes. We discuss our findings in the context of relevant genetic and epidemiological literature, as well as the limitations and caveats of the study.Source
bioRxiv 070730; doi: https://doi.org/10.1101/070730. Link to preprint on bioRxiv service.
DOI
10.1101/070730Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29304Notes
Full author list omitted for brevity. For the full list of authors, see article.
Rights
The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1101/070730
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Except where otherwise noted, this item's license is described as The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.