Authors
Dekker, JobBelmont, Andrew S.
Guttman, Mitchell
Leshyk, Victor O.
Lis, John T.
Lomvardas, Stavros
Mirny, Leonid A.
O'Shea, Clodagh C.
Park, Peter J.
Ren, Bing
Ritland Politz, Joan C.
Shendure, Jay
Zong, Sheng
4D Nucleome Network
Parsi, Krishna M.
Maehr, Rene
Sontheimer, Erik J.
Grunwald, David
Kaufman, Paul D.
Zhu, Lihua (Julie)
UMass Chan Affiliations
Department of Molecular, Cell and Cancer BiologyRNA Therapeutics Institute
Program in Molecular Medicine
Department of Biochemistry and Molecular Pharmacology
Program in Systems Biology
Document Type
PreprintPublication Date
2017-01-26Keywords
genomics4D Nucleome Network
gene expression
cellular function
Amino Acids, Peptides, and Proteins
Biochemistry
Genetic Phenomena
Genomics
Molecular Biology
Structural Biology
Metadata
Show full item recordAbstract
The spatial organization of the genome and its dynamics contribute to gene expression and cellular function in normal development as well as in disease. Although we are increasingly well equipped to determine a genome's sequence and linear chromatin composition, studying the three-dimensional organization of the genome with high spatial and temporal resolution remains challenging. The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the long term goal of gaining deeper mechanistic understanding of how the nucleus is organized. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Further efforts will be directed at applying validated experimental approaches combined with biophysical modeling to generate integrated maps and quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.Source
bioRxiv 103499; doi: https://doi.org/10.1101/103499. Link to preprint on bioRxiv service.
DOI
10.1101/103499Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29334Notes
Members of the 4D Nucleome Network from UMass Medical School who collaborated on this project include Krishna M. Parsi, Rene Maehr, Erik J. Sontheimer, David Grunwald, Paul D. Kaufman, and Lihua (Julie) Zhu.
Related Resources
Now published in Nature doi: 10.1038/nature23884.
Rights
The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1101/103499
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Except where otherwise noted, this item's license is described as The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.