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dc.contributor.authorDekker, Job
dc.contributor.authorBelmont, Andrew S.
dc.contributor.authorGuttman, Mitchell
dc.contributor.authorLeshyk, Victor O.
dc.contributor.authorLis, John T.
dc.contributor.authorLomvardas, Stavros
dc.contributor.authorMirny, Leonid A.
dc.contributor.authorO'Shea, Clodagh C.
dc.contributor.authorPark, Peter J.
dc.contributor.authorRen, Bing
dc.contributor.authorRitland Politz, Joan C.
dc.contributor.authorShendure, Jay
dc.contributor.authorZong, Sheng
dc.contributor.author4D Nucleome Network
dc.contributor.authorParsi, Krishna Mohan
dc.contributor.authorMaehr, Rene
dc.contributor.authorSontheimer, Erik J.
dc.contributor.authorGrunwald, David
dc.contributor.authorKaufman, Paul D.
dc.contributor.authorZhu, Lihua (Julie)
dc.date2022-08-11T08:08:23.000
dc.date.accessioned2022-08-23T15:53:20Z
dc.date.available2022-08-23T15:53:20Z
dc.date.issued2017-01-26
dc.date.submitted2018-06-21
dc.identifier.citation<p>bioRxiv 103499; doi: https://doi.org/10.1101/103499. <a href="https://doi.org/10.1101/103499" target="_blank">Link to preprint on bioRxiv service.</a></p>
dc.identifier.doi10.1101/103499
dc.identifier.urihttp://hdl.handle.net/20.500.14038/29334
dc.description<p>Members of the 4D Nucleome Network from UMass Medical School who collaborated on this project include Krishna M. Parsi, Rene Maehr, Erik J. Sontheimer, David Grunwald, Paul D. Kaufman, and Lihua (Julie) Zhu.</p>
dc.description.abstractThe spatial organization of the genome and its dynamics contribute to gene expression and cellular function in normal development as well as in disease. Although we are increasingly well equipped to determine a genome's sequence and linear chromatin composition, studying the three-dimensional organization of the genome with high spatial and temporal resolution remains challenging. The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the long term goal of gaining deeper mechanistic understanding of how the nucleus is organized. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Further efforts will be directed at applying validated experimental approaches combined with biophysical modeling to generate integrated maps and quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.
dc.language.isoen_US
dc.relation<p>Now published in <em>Nature</em> doi: <a href="http://dx.doi.org/10.1038/nature23884" target="_blank">10.1038/nature23884</a>.</p>
dc.rightsThe copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectgenomics
dc.subject4D Nucleome Network
dc.subjectgene expression
dc.subjectcellular function
dc.subjectAmino Acids, Peptides, and Proteins
dc.subjectBiochemistry
dc.subjectGenetic Phenomena
dc.subjectGenomics
dc.subjectMolecular Biology
dc.subjectStructural Biology
dc.titleThe 4D Nucleome Project [preprint]
dc.typePreprint
dc.source.journaltitlebioRxiv
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2570&amp;context=faculty_pubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/1560
dc.identifier.contextkey12351092
refterms.dateFOA2022-08-23T15:53:21Z
html.description.abstract<p>The spatial organization of the genome and its dynamics contribute to gene expression and cellular function in normal development as well as in disease. Although we are increasingly well equipped to determine a genome's sequence and linear chromatin composition, studying the three-dimensional organization of the genome with high spatial and temporal resolution remains challenging. The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the long term goal of gaining deeper mechanistic understanding of how the nucleus is organized. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Further efforts will be directed at applying validated experimental approaches combined with biophysical modeling to generate integrated maps and quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.</p>
dc.identifier.submissionpathfaculty_pubs/1560
dc.contributor.departmentDepartment of Molecular, Cell and Cancer Biology
dc.contributor.departmentRNA Therapeutics Institute
dc.contributor.departmentProgram in Molecular Medicine
dc.contributor.departmentDepartment of Biochemistry and Molecular Pharmacology
dc.contributor.departmentProgram in Systems Biology


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The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.
Except where otherwise noted, this item's license is described as The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.