Show simple item record

dc.contributor.authorCook, Daniel E.
dc.contributor.authorZdraljevic, Stefan
dc.contributor.authorTanny, Robyn E.
dc.contributor.authorSeo, Beomseok
dc.contributor.authorRiccardi, David
dc.contributor.authorNoble, Luke M.
dc.contributor.authorRockman, Matthew V.
dc.contributor.authorAlkema, Mark J.
dc.contributor.authorBraendle, Christian
dc.contributor.authorKammenga, Jan
dc.contributor.authorWang, John
dc.contributor.authorKruglyak, Leonid
dc.contributor.authorFelix, Marie-Anne
dc.contributor.authorLee, Junho
dc.contributor.authorAndersen, Erik
dc.date2022-08-11T08:08:23.000
dc.date.accessioned2022-08-23T15:53:25Z
dc.date.available2022-08-23T15:53:25Z
dc.date.issued2016-05-02
dc.date.submitted2018-06-25
dc.identifier.citation<p>bioRxiv 051276; doi: https://doi.org/10.1101/051276. <a href="https://doi.org/10.1101/051276" target="_blank">Link to preprint on bioRxiv service.</a></p>
dc.identifier.doi10.1101/051276
dc.identifier.urihttp://hdl.handle.net/20.500.14038/29348
dc.description.abstractTelomeres are involved in the maintenance of chromosomes and the prevention of genome instability. Despite this central importance, significant variation in telomere length has been observed in a variety of organisms. The genetic determinants of telomere-length variation and their effects on organismal fitness are largely unexplored. Here, we describe natural variation in telomere length across the Caenorhabditis elegans species. We identify a large-effect variant that contributes to differences in telomere length. The variant alters the conserved oligosaccharide/oligonucleotide-binding fold of POT-2, a homolog of a human telomere-capping shelterin complex subunit. Mutations within this domain likely reduce the ability of POT-2 to bind telomeric DNA, thereby increasing telomere length. We find that telomere-length variation does not correlate with offspring production or longevity in C. elegans wild isolates, suggesting that naturally long telomeres play a limited role in modifying fitness phenotypes in C. elegans.
dc.language.isoen_US
dc.rightsThe copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectgenetics
dc.subjecttelomere length
dc.subjectCaenorhabditis elegans
dc.subjectPOT-2
dc.subjectGenetic Phenomena
dc.subjectGenetics
dc.subjectPopulation Biology
dc.titleThe genetic basis of natural variation in C. elegans telomere length [preprint]
dc.typePreprint
dc.source.journaltitlebioRxiv
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2583&amp;context=faculty_pubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/1573
dc.identifier.contextkey12365510
refterms.dateFOA2022-08-23T15:53:25Z
html.description.abstract<p>Telomeres are involved in the maintenance of chromosomes and the prevention of genome instability. Despite this central importance, significant variation in telomere length has been observed in a variety of organisms. The genetic determinants of telomere-length variation and their effects on organismal fitness are largely unexplored. Here, we describe natural variation in telomere length across the Caenorhabditis elegans species. We identify a large-effect variant that contributes to differences in telomere length. The variant alters the conserved oligosaccharide/oligonucleotide-binding fold of POT-2, a homolog of a human telomere-capping shelterin complex subunit. Mutations within this domain likely reduce the ability of POT-2 to bind telomeric DNA, thereby increasing telomere length. We find that telomere-length variation does not correlate with offspring production or longevity in C. elegans wild isolates, suggesting that naturally long telomeres play a limited role in modifying fitness phenotypes in C. elegans.</p>
dc.identifier.submissionpathfaculty_pubs/1573
dc.contributor.departmentAlkema Lab
dc.contributor.departmentDepartment of Neurobiology


Files in this item

Thumbnail
Name:
051276.full.pdf
Size:
1.660Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.
Except where otherwise noted, this item's license is described as The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.