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    Nuclear organization mediates cancer-compromised genetic and epigenetic control

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    Authors
    Zaidi, Sayyed K.
    Fritz, Andrew J.
    Tracy, Kirsten M.
    Gordon, Jonathan A.
    Tye, Coralee E.
    Boyd, Joseph
    Van Wijnen, Andre J.
    Nickerson, Jeffrey A.
    Imbalzano, Anthony N.
    Lian, Jane B.
    Stein, Janet L.
    Stein, Gary S.
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    UMass Chan Affiliations
    Imbalzano Lab
    Nickerson Lab
    UMass Metabolic Network
    Department of Biochemistry and Molecular Pharmacology
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    2018-05-09
    Keywords
    Cancer Biology
    Cell Biology
    Cellular and Molecular Physiology
    
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    Link to Full Text
    https://doi.org/10.1016/j.jbior.2018.05.001
    Abstract
    Nuclear organization is functionally linked to genetic and epigenetic regulation of gene expression for biological control and is modified in cancer. Nuclear organization supports cell growth and phenotypic properties of normal and cancer cells by facilitating physiologically responsive interactions of chromosomes, genes and regulatory complexes at dynamic three-dimensional microenvironments. We will review nuclear structure/function relationships that include: 1. Epigenetic bookmarking of genes by phenotypic transcription factors to control fidelity and plasticity of gene expression as cells enter and exit mitosis; 2. Contributions of chromatin remodeling to breast cancer nuclear morphology, metabolism and effectiveness of chemotherapy; 3. Relationships between fidelity of nuclear organization and metastasis of breast cancer to bone; 4. Dynamic modifications of higher-order inter- and intra-chromosomal interactions in breast cancer cells; 5. Coordinate control of cell growth and phenotype by tissue-specific transcription factors; 6. Oncofetal epigenetic control by bivalent histone modifications that are functionally related to sustaining the stem cell phenotype; and 7. Noncoding RNA-mediated regulation in the onset and progression of breast cancer. The discovery of components to nuclear organization that are functionally related to cancer and compromise gene expression have the potential for translation to innovative cancer diagnosis and targeted therapy.
    Source

    Adv Biol Regul. 2018 May 9. pii: S2212-4926(18)30078-2. doi: 10.1016/j.jbior.2018.05.001. [Epub ahead of print] Link to article on publisher's site

    DOI
    10.1016/j.jbior.2018.05.001
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/29363
    PubMed ID
    29759441
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jbior.2018.05.001
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