Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer
UMass Chan Affiliations
Nickerson LabImbalzano Lab
Department of Biochemistry and Molecular Pharmacology
Division of Genes and Development, Department of Pediatrics
Document Type
Journal ArticlePublication Date
2019-07-01Keywords
RUNXbreast cancer
cancer stem cells
epithelial to mesenchymal transition
higher order chromatin organization
hormone regulation
mitotic bookmarking
Amino Acids, Peptides, and Proteins
Biochemistry, Biophysics, and Structural Biology
Cancer Biology
Cell Biology
Cells
Genetic Phenomena
Genetics and Genomics
Neoplasms
Metadata
Show full item recordAbstract
Cells establish and sustain structural and functional integrity of the genome to support cellular identity and prevent malignant transformation. In this review, we present a strategic overview of epigenetic regulatory mechanisms including histone modifications and higher order chromatin organization (HCO) that are perturbed in breast cancer onset and progression. Implications for dysfunctions that occur in hormone regulation, cell cycle control, and mitotic bookmarking in breast cancer are considered, with an emphasis on epithelial-to-mesenchymal transition and cancer stem cell activities. The architectural organization of regulatory machinery is addressed within the contexts of translating cancer-compromised genomic organization to advances in breast cancer risk assessment, diagnosis, prognosis, and identification of novel therapeutic targets with high specificity and minimal off target effects.Source
Genes Chromosomes Cancer. 2019 Jul;58(7):484-499. doi: 10.1002/gcc.22731. Epub 2019 Mar 15. Link to article on publisher's site
DOI
10.1002/gcc.22731Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29406PubMed ID
30873710Notes
Full author list omitted for brevity. For the full list of authors, see article.
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10.1002/gcc.22731