Jumping over the fence: RNA nuclear export revisited
UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Response or CommentPublication Date
2013-03-01Keywords
Nuclear EnvelopeNuclear Pore
nuclear envelope
nuclear lamina
nuclear pore complex
Wnt sig-naling
neuromuscular junctions
RNA export
Cells
Genetic PhenomenaMolecular BiologyMolecular GeneticsNucleic Acids, Nucleotides, and Nucleosides
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Show full item recordAbstract
The nuclear envelope forms a cocoon that surrounds the cellular genome keeping it out of harm's way and can be utilized by the cell as a means of functionally regulating chromatin structure and gene expression. At the same time, this double-layered membrane system constitutes a formidable obstacle to the unimpeded flow of genetic information between the genome and the rest of the cell. The nuclear pore has been long considered the sole passageway between nucleus and cytoplasm. A new report challenges this view and proposes a novel mechanism by which RNA transcripts destined for localized translation in highly polarized cell types, cross both inner and outer nuclear envelope membranes and reach the cytoplasm without utilizing the nuclear pore route.Source
Nucleus. 2013 Mar-Apr;4(2):95-9. doi: 10.4161/nucl.24237. Epub 2013 Mar 1. Link to article on publisher's site
DOI
10.4161/nucl.24237Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29497PubMed ID
23528257Related Resources
Rights
This is an Open Access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may redistributed, reproduced and reused for non-commercial purposes, provided the original source is properly cited.Scopus Count
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