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    Choosing anatomical-prior strength for MAP SPECT reconstruction to maximize lesion detectability

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    Authors
    Lehovich, Andre
    Gifford, Howard C.
    Schneider, Peter B.
    King, Michael A.
    UMass Chan Affiliations
    Department of Radiology
    Document Type
    Conference Paper
    Publication Date
    2007-10-26
    Keywords
    Lesions
    Image reconstruction
    Computed tomography
    Humans
    Testing
    Anatomy
    Computational modeling
    Iterative algorithms
    Feedback
    Predictive models
    Analytical, Diagnostic and Therapeutic Techniques and Equipment
    Bioimaging and Biomedical Optics
    Biological and Chemical Physics
    Nuclear
    Nuclear Engineering
    Radiology
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/pmc2749318/
    Abstract
    With the widespread availability of SPECT/CT systems it has become feasible to incorporate prior knowledge about anatomical boundaries into the SPECT reconstruction process, thus improving observer performance on tasks of clinical interest. We determine the optimal anatomical-prior strength for lesion search by measuring area under the LROC curve using human observers. We conclude that prior strength should be chosen assuming that only organ boundaries are available, even if lesion boundaries will also be known some of the time. We also test whether or not the presence of anatomical priors affects the observer's strategy, and conclude that mixing images with and without priors does not hurt reader performance when priors are not available. Finally, we examine whether using an anatomical prior in SPECT reconstruction helps observer performance when the observer already knows the possible lesion location, and conclude for this task anatomical priors do not provide the same improvement seen in search tasks.
    Source

    Lehovich A, Gifford HC, Schneider PB, King MA. Choosing anatomical-prior strength for MAP SPECT reconstruction to maximize lesion detectability. IEEE Nucl Sci Symp Conf Rec (1997). 2007 Oct 26;6(1):4222-4225. doi: 10.1109/NSSMIC.2007.4437049. PMID: 19779594; PMCID: PMC2749318. Link to article on publisher's site

    DOI
    10.1109/NSSMIC.2007.4437049
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/29531
    PubMed ID
    19779594
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1109/NSSMIC.2007.4437049
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    UMass Chan Faculty and Researcher Publications
    Radiology Publications

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