PFRED: A computational platform for siRNA and antisense oligonucleotides design [preprint]
Authors
Sciabola, SimoneXi, Hualin
Cruz, Dario
Cao, Qing
Lawrence, Christine
Zhang, Tianhong
Rotstein, Sergio
Hughes, Jason D.
Caffrey, Daniel R.
Stanton, Robert
UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
PreprintPublication Date
2020-08-25Keywords
bioinformaticssiRNA
antisense oligonucleotides
PFRED
open source
software platform
Bioinformatics
Computational Biology
Nucleic Acids, Nucleotides, and Nucleosides
Metadata
Show full item recordAbstract
PFRED a software application for the design, analysis, and visualization of antisense oligonucleotides and siRNA is described. The software provides an intuitive user-interface for scientists to design a library of siRNA or antisense oligonucleotides that target a specific gene of interest. Moreover, the tool facilitates the incorporation of various design criteria that have been shown to be important for stability and potency. PFRED has been made available as an open-source project so the code can be easily modified to address the future needs of the oligonucleotide research community. A compiled version is available for downloading at https://github.com/pfred/pfred-gui/releases as a java Jar file. The source code and the links for downloading the precompiled version can be found at https://github.com/pfred.Source
bioRxiv 2020.08.25.265983; doi: https://doi.org/10.1101/2020.08.25.265983. Link to preprint on bioRxiv service.
DOI
10.1101/2020.08.25.265983Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29545Rights
The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.Distribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.1101/2020.08.25.265983
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Except where otherwise noted, this item's license is described as The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license.