Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity
UMass Chan AffiliationsProgram in Bioinformatics and Integrative Biology
Program in Molecular Medicine
Document TypeJournal Article
naked mole rat
Biochemical Phenomena, Metabolism, and Nutrition
Comparative and Evolutionary Physiology
Ecology and Evolutionary Biology
Genetics and Genomics
MetadataShow full item record
AbstractLong-lived rodents have become an attractive model for the studies on aging. To understand evolutionary paths to long life, we prepare chromosome-level genome assemblies of the two longest-lived rodents, Canadian beaver (Castor canadensis) and naked mole rat (NMR, Heterocephalus glaber), which were scaffolded with in vitro proximity ligation and chromosome conformation capture data and complemented with long-read sequencing. Our comparative genomic analyses reveal that amino acid substitutions at "disease-causing" sites are widespread in the rodent genomes and that identical substitutions in long-lived rodents are associated with common adaptive phenotypes, e.g., enhanced resistance to DNA damage and cellular stress. By employing a newly developed substitution model and likelihood ratio test, we find that energy and fatty acid metabolism pathways are enriched for signals of positive selection in both long-lived rodents. Thus, the high-quality genome resource of long-lived rodents can assist in the discovery of genetic factors that control longevity and adaptive evolution.
Zhou X, Dou Q, Fan G, Zhang Q, Sanderford M, Kaya A, Johnson J, Karlsson EK, Tian X, Mikhalchenko A, Kumar S, Seluanov A, Zhang ZD, Gorbunova V, Liu X, Gladyshev VN. Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity. Cell Rep. 2020 Jul 28;32(4):107949. doi: 10.1016/j.celrep.2020.107949. PMID: 32726638. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/29565
Full author list omitted for brevity. For the full list of authors, see article.