Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity
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UMass Chan Affiliations
Program in Bioinformatics and Integrative BiologyProgram in Molecular Medicine
Document Type
Journal ArticlePublication Date
2020-07-28Keywords
agingbeaver
chromosome-level assembly
evolutionary analyses
gene expression
genome
long-lived rodents
longevity
naked mole rat
stress resistance
Biochemical Phenomena, Metabolism, and Nutrition
Comparative and Evolutionary Physiology
Ecology and Evolutionary Biology
Genetics and Genomics
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Show full item recordAbstract
Long-lived rodents have become an attractive model for the studies on aging. To understand evolutionary paths to long life, we prepare chromosome-level genome assemblies of the two longest-lived rodents, Canadian beaver (Castor canadensis) and naked mole rat (NMR, Heterocephalus glaber), which were scaffolded with in vitro proximity ligation and chromosome conformation capture data and complemented with long-read sequencing. Our comparative genomic analyses reveal that amino acid substitutions at "disease-causing" sites are widespread in the rodent genomes and that identical substitutions in long-lived rodents are associated with common adaptive phenotypes, e.g., enhanced resistance to DNA damage and cellular stress. By employing a newly developed substitution model and likelihood ratio test, we find that energy and fatty acid metabolism pathways are enriched for signals of positive selection in both long-lived rodents. Thus, the high-quality genome resource of long-lived rodents can assist in the discovery of genetic factors that control longevity and adaptive evolution.Source
Zhou X, Dou Q, Fan G, Zhang Q, Sanderford M, Kaya A, Johnson J, Karlsson EK, Tian X, Mikhalchenko A, Kumar S, Seluanov A, Zhang ZD, Gorbunova V, Liu X, Gladyshev VN. Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity. Cell Rep. 2020 Jul 28;32(4):107949. doi: 10.1016/j.celrep.2020.107949. PMID: 32726638. Link to article on publisher's site
DOI
10.1016/j.celrep.2020.107949Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29565PubMed ID
32726638Notes
Full author list omitted for brevity. For the full list of authors, see article.
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Rights
Copyright 2020 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1016/j.celrep.2020.107949
Scopus Count
Except where otherwise noted, this item's license is described as Copyright 2020 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).