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dc.contributor.authorLutz, Jacqueline
dc.contributor.authorBerry, Michael P.
dc.contributor.authorNapadow, Vitaly
dc.contributor.authorGermer, Christopher
dc.contributor.authorPollak, Susan
dc.contributor.authorGardiner, Paula
dc.contributor.authorEdwards, Robert R.
dc.contributor.authorDesbordes, Gaelle
dc.contributor.authorSchuman-Olivier, Zev
dc.date2022-08-11T08:08:25.000
dc.date.accessioned2022-08-23T15:54:37Z
dc.date.available2022-08-23T15:54:37Z
dc.date.issued2020-07-30
dc.date.submitted2020-09-22
dc.identifier.citation<p>Lutz J, Berry MP, Napadow V, Germer C, Pollak S, Gardiner P, Edwards RR, Desbordes G, Schuman-Olivier Z. Neural activations during self-related processing in patients with chronic pain and effects of a brief self-compassion training - A pilot study. Psychiatry Res Neuroimaging. 2020 Oct 30;304:111155. doi: 10.1016/j.pscychresns.2020.111155. Epub 2020 Jul 30. PMID: 32799058. <a href="https://doi.org/10.1016/j.pscychresns.2020.111155">Link to article on publisher's site</a></p>
dc.identifier.issn0925-4927 (Linking)
dc.identifier.doi10.1016/j.pscychresns.2020.111155
dc.identifier.pmid32799058
dc.identifier.urihttp://hdl.handle.net/20.500.14038/29590
dc.description.abstractChronic pain negatively affects psychological functioning including self-perception. Self-compassion may improve self-related functioning in patients with chronic pain but understanding of the neural mechanisms is limited. In this study, twenty patients with chronic low back pain read negative self-related situations and were instructed to be either self-reassuring or self-critical while undergoing fMRI. Patients rated their feelings of self-reassurance and self-criticism during each condition, and brain responses were contrasted with neutral instructions. Trait self-compassion measures (SCS) were also acquired. Brain activations during self-criticism and self-reassurance were localized to prefrontal, self- and emotion-processing areas, such as medial prefrontal cortex, dorsolateral prefrontal cortex (dlPFC), dorsal anterior cingulate cortex and posterior cingulate cortex. Self-reassurance resulted in more widespread and stronger activations relative to self-criticism. Patients then completed a brief self-compassion training (8 contact hours, 2 weeks home practice). Exploratory pre-post comparisons in thirteen patients found that feelings of self-criticism were significantly reduced and brain activations were greater in the anterior insula and prefrontal cortical regions such as dlPFC. Pre-post increases in dlPFC activation correlated with increased self-compassion (SCS), suggesting that early self-compassion skills might primarily target self-criticism via dlPFC upregulation. Future controlled studies on self-compassion training in chronic pain populations should extend these results.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=32799058&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1016/j.pscychresns.2020.111155
dc.subjectcorticial midline regions
dc.subjectdorsolateral prefrontal cortex
dc.subjectemotion regulation
dc.subjectfMRI
dc.subjectinsula
dc.subjectpain
dc.subjectprefrontal cortex
dc.subjectself-compassion
dc.subjectself-criticism
dc.subjectself-related processes
dc.subjectCognition and Perception
dc.subjectHealth Services Administration
dc.subjectHealth Services Research
dc.subjectNeuroscience and Neurobiology
dc.subjectPain Management
dc.subjectPsychiatry and Psychology
dc.titleNeural activations during self-related processing in patients with chronic pain and effects of a brief self-compassion training - A pilot study
dc.typeJournal Article
dc.source.journaltitlePsychiatry research. Neuroimaging
dc.source.volume304
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/1809
dc.identifier.contextkey19508492
html.description.abstract<p>Chronic pain negatively affects psychological functioning including self-perception. Self-compassion may improve self-related functioning in patients with chronic pain but understanding of the neural mechanisms is limited. In this study, twenty patients with chronic low back pain read negative self-related situations and were instructed to be either self-reassuring or self-critical while undergoing fMRI. Patients rated their feelings of self-reassurance and self-criticism during each condition, and brain responses were contrasted with neutral instructions. Trait self-compassion measures (SCS) were also acquired. Brain activations during self-criticism and self-reassurance were localized to prefrontal, self- and emotion-processing areas, such as medial prefrontal cortex, dorsolateral prefrontal cortex (dlPFC), dorsal anterior cingulate cortex and posterior cingulate cortex. Self-reassurance resulted in more widespread and stronger activations relative to self-criticism. Patients then completed a brief self-compassion training (8 contact hours, 2 weeks home practice). Exploratory pre-post comparisons in thirteen patients found that feelings of self-criticism were significantly reduced and brain activations were greater in the anterior insula and prefrontal cortical regions such as dlPFC. Pre-post increases in dlPFC activation correlated with increased self-compassion (SCS), suggesting that early self-compassion skills might primarily target self-criticism via dlPFC upregulation. Future controlled studies on self-compassion training in chronic pain populations should extend these results.</p>
dc.identifier.submissionpathfaculty_pubs/1809
dc.contributor.departmentCenter for Integrated Primary Care
dc.contributor.departmentDepartment of Family Medicine and Community Health
dc.source.pages111155


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