Neural activations during self-related processing in patients with chronic pain and effects of a brief self-compassion training - A pilot study
dc.contributor.author | Lutz, Jacqueline | |
dc.contributor.author | Berry, Michael P. | |
dc.contributor.author | Napadow, Vitaly | |
dc.contributor.author | Germer, Christopher | |
dc.contributor.author | Pollak, Susan | |
dc.contributor.author | Gardiner, Paula | |
dc.contributor.author | Edwards, Robert R. | |
dc.contributor.author | Desbordes, Gaelle | |
dc.contributor.author | Schuman-Olivier, Zev | |
dc.date | 2022-08-11T08:08:25.000 | |
dc.date.accessioned | 2022-08-23T15:54:37Z | |
dc.date.available | 2022-08-23T15:54:37Z | |
dc.date.issued | 2020-07-30 | |
dc.date.submitted | 2020-09-22 | |
dc.identifier.citation | <p>Lutz J, Berry MP, Napadow V, Germer C, Pollak S, Gardiner P, Edwards RR, Desbordes G, Schuman-Olivier Z. Neural activations during self-related processing in patients with chronic pain and effects of a brief self-compassion training - A pilot study. Psychiatry Res Neuroimaging. 2020 Oct 30;304:111155. doi: 10.1016/j.pscychresns.2020.111155. Epub 2020 Jul 30. PMID: 32799058. <a href="https://doi.org/10.1016/j.pscychresns.2020.111155">Link to article on publisher's site</a></p> | |
dc.identifier.issn | 0925-4927 (Linking) | |
dc.identifier.doi | 10.1016/j.pscychresns.2020.111155 | |
dc.identifier.pmid | 32799058 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/29590 | |
dc.description.abstract | Chronic pain negatively affects psychological functioning including self-perception. Self-compassion may improve self-related functioning in patients with chronic pain but understanding of the neural mechanisms is limited. In this study, twenty patients with chronic low back pain read negative self-related situations and were instructed to be either self-reassuring or self-critical while undergoing fMRI. Patients rated their feelings of self-reassurance and self-criticism during each condition, and brain responses were contrasted with neutral instructions. Trait self-compassion measures (SCS) were also acquired. Brain activations during self-criticism and self-reassurance were localized to prefrontal, self- and emotion-processing areas, such as medial prefrontal cortex, dorsolateral prefrontal cortex (dlPFC), dorsal anterior cingulate cortex and posterior cingulate cortex. Self-reassurance resulted in more widespread and stronger activations relative to self-criticism. Patients then completed a brief self-compassion training (8 contact hours, 2 weeks home practice). Exploratory pre-post comparisons in thirteen patients found that feelings of self-criticism were significantly reduced and brain activations were greater in the anterior insula and prefrontal cortical regions such as dlPFC. Pre-post increases in dlPFC activation correlated with increased self-compassion (SCS), suggesting that early self-compassion skills might primarily target self-criticism via dlPFC upregulation. Future controlled studies on self-compassion training in chronic pain populations should extend these results. | |
dc.language.iso | en_US | |
dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=32799058&dopt=Abstract">Link to Article in PubMed</a></p> | |
dc.relation.url | https://doi.org/10.1016/j.pscychresns.2020.111155 | |
dc.subject | corticial midline regions | |
dc.subject | dorsolateral prefrontal cortex | |
dc.subject | emotion regulation | |
dc.subject | fMRI | |
dc.subject | insula | |
dc.subject | pain | |
dc.subject | prefrontal cortex | |
dc.subject | self-compassion | |
dc.subject | self-criticism | |
dc.subject | self-related processes | |
dc.subject | Cognition and Perception | |
dc.subject | Health Services Administration | |
dc.subject | Health Services Research | |
dc.subject | Neuroscience and Neurobiology | |
dc.subject | Pain Management | |
dc.subject | Psychiatry and Psychology | |
dc.title | Neural activations during self-related processing in patients with chronic pain and effects of a brief self-compassion training - A pilot study | |
dc.type | Journal Article | |
dc.source.journaltitle | Psychiatry research. Neuroimaging | |
dc.source.volume | 304 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/faculty_pubs/1809 | |
dc.identifier.contextkey | 19508492 | |
html.description.abstract | <p>Chronic pain negatively affects psychological functioning including self-perception. Self-compassion may improve self-related functioning in patients with chronic pain but understanding of the neural mechanisms is limited. In this study, twenty patients with chronic low back pain read negative self-related situations and were instructed to be either self-reassuring or self-critical while undergoing fMRI. Patients rated their feelings of self-reassurance and self-criticism during each condition, and brain responses were contrasted with neutral instructions. Trait self-compassion measures (SCS) were also acquired. Brain activations during self-criticism and self-reassurance were localized to prefrontal, self- and emotion-processing areas, such as medial prefrontal cortex, dorsolateral prefrontal cortex (dlPFC), dorsal anterior cingulate cortex and posterior cingulate cortex. Self-reassurance resulted in more widespread and stronger activations relative to self-criticism. Patients then completed a brief self-compassion training (8 contact hours, 2 weeks home practice). Exploratory pre-post comparisons in thirteen patients found that feelings of self-criticism were significantly reduced and brain activations were greater in the anterior insula and prefrontal cortical regions such as dlPFC. Pre-post increases in dlPFC activation correlated with increased self-compassion (SCS), suggesting that early self-compassion skills might primarily target self-criticism via dlPFC upregulation. Future controlled studies on self-compassion training in chronic pain populations should extend these results.</p> | |
dc.identifier.submissionpath | faculty_pubs/1809 | |
dc.contributor.department | Center for Integrated Primary Care | |
dc.contributor.department | Department of Family Medicine and Community Health | |
dc.source.pages | 111155 |