The meadow jumping mouse genome and transcriptome suggest mechanisms of hibernation [preprint]
Authors
Cong, QianBrem, Ethan A.
Zhang, Jing
Alfoldi, Jessica
Johnson, Jeremy
Karlsson, Elinor K.
Lindblad-Toh, Kerstin
Malaney, Jason L.
Israelsen, William J.
UMass Chan Affiliations
Program in Bioinformatics and Integrative BiologyDocument Type
PreprintPublication Date
2020-11-03Keywords
Genomicshibernation
meadow jumping mouse
phenotypes
Biochemical Phenomena, Metabolism, and Nutrition
Bioinformatics
Genomics
Physiological Processes
Zoology
Metadata
Show full item recordAbstract
Hibernating mammals exhibit medically relevant phenotypes, but the genetic basis of hibernation remains poorly understood. Using the meadow jumping mouse (Zapus hudsonius), we investigated the genetic underpinnings of hibernation by uniting experimental and comparative genomic approaches. We assembled a Z. hudsonius genome and identified widespread expression changes during hibernation in genes important for circadian rhythm, membrane fluidity, and cell cycle arrest. Tissue-specific gene expression changes during torpor encompassed Wnt signaling in the brain and structural and transport functions in the kidney brush border. Using genomes from the closely related Zapus oregonus (previously classified as Z. princeps) and leveraging a panel of hibernating and non-hibernating rodents, we found selective pressure on genes involved in feeding behavior, metabolism, and cell biological processes potentially important for function at low body temperature. Leptin stands out with elevated conservation in hibernating rodents, implying a role for this metabolic hormone in triggering fattening and hibernation. These findings illustrate that mammalian hibernation requires adaptation at all levels of organismal form and function and lay the groundwork for future study of hibernation phenotypes.Source
bioRxiv 2020.11.02.365791; doi: https://doi.org/10.1101/2020.11.02.365791. Link to preprint on bioRxiv
DOI
10.1101/2020.11.02.365791Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29626Notes
This article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.
Rights
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1101/2020.11.02.365791
Scopus Count
Except where otherwise noted, this item's license is described as The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.