UMass Chan AffiliationsDepartment of Biochemistry and Molecular Pharmacology
KeywordsEndoplasmic Reticulum, Rough
Biochemistry, Biophysics, and Structural Biology
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AbstractThe rough endoplasmic reticulum is a major site of protein biosynthesis in all eukaryotic cells, serving as the entry point for the secretory pathway and as the initial integration site for the majority of cellular integral membrane proteins. The core components of the protein translocation machinery have been identified, and high-resolution structures of the targeting components and the transport channel have been obtained. Research in this area is now focused on obtaining a better understanding of the molecular mechanism of protein translocation and membrane protein integration.
SourceCold Spring Harb Perspect Biol. 2013 Feb 1;5(2). pii: a013342. doi: 10.1101/cshperspect.a013342. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/29665
Related ResourcesLink to Article in PubMed