Protein translocation across the rough endoplasmic reticulum
| dc.contributor.author | Mandon, Elisabet C. | |
| dc.contributor.author | Trueman, Steven F. | |
| dc.contributor.author | Gilmore, Reid | |
| dc.date | 2022-08-11T08:08:26.000 | |
| dc.date.accessioned | 2022-08-23T15:55:02Z | |
| dc.date.available | 2022-08-23T15:55:02Z | |
| dc.date.issued | 2013-02-01 | |
| dc.date.submitted | 2013-07-09 | |
| dc.identifier.citation | Cold Spring Harb Perspect Biol. 2013 Feb 1;5(2). pii: a013342. doi: 10.1101/cshperspect.a013342. <a href="http://dx.doi.org/10.1101/cshperspect.a013342" target="_blank">Link to article on publisher's site</a> | |
| dc.identifier.issn | 1943-0264 (Electronic) | |
| dc.identifier.doi | 10.1101/cshperspect.a013342 | |
| dc.identifier.pmid | 23251026 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/29665 | |
| dc.description.abstract | The rough endoplasmic reticulum is a major site of protein biosynthesis in all eukaryotic cells, serving as the entry point for the secretory pathway and as the initial integration site for the majority of cellular integral membrane proteins. The core components of the protein translocation machinery have been identified, and high-resolution structures of the targeting components and the transport channel have been obtained. Research in this area is now focused on obtaining a better understanding of the molecular mechanism of protein translocation and membrane protein integration. | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23251026&dopt=Abstract">Link to Article in PubMed</a> | |
| dc.relation.url | http://dx.doi.org/10.1101/cshperspect.a013342 | |
| dc.subject | Endoplasmic Reticulum, Rough | |
| dc.subject | Protein Transport | |
| dc.subject | Biochemistry, Biophysics, and Structural Biology | |
| dc.subject | Cell Biology | |
| dc.title | Protein translocation across the rough endoplasmic reticulum | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Cold Spring Harbor perspectives in biology | |
| dc.source.volume | 5 | |
| dc.source.issue | 2 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/faculty_pubs/188 | |
| dc.identifier.contextkey | 4297398 | |
| html.description.abstract | <p>The rough endoplasmic reticulum is a major site of protein biosynthesis in all eukaryotic cells, serving as the entry point for the secretory pathway and as the initial integration site for the majority of cellular integral membrane proteins. The core components of the protein translocation machinery have been identified, and high-resolution structures of the targeting components and the transport channel have been obtained. Research in this area is now focused on obtaining a better understanding of the molecular mechanism of protein translocation and membrane protein integration.</p> | |
| dc.identifier.submissionpath | faculty_pubs/188 | |
| dc.contributor.department | Department of Biochemistry and Molecular Pharmacology |