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    Diversity and Function of Glial Cell Types in Multiple Sclerosis

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    Authors
    Schirmer, Lucas
    Schafer, Dorothy P
    Bartels, Theresa
    Rowitch, David H.
    Calabresi, Peter A.
    UMass Chan Affiliations
    Schafer Lab
    Brudnick Neuropsychiatric Research Institute
    Neurobiology
    Document Type
    Journal Article
    Publication Date
    2021-03-01
    Keywords
    astrocytes
    microglia
    multiple sclerosis
    neuroinflammation
    oligodendrocytes
    transcriptomics
    Immune System Diseases
    Immunity
    Immunopathology
    Molecular and Cellular Neuroscience
    Nervous System Diseases
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    Link to Full Text
    https://doi.org/10.1016/j.it.2021.01.005
    Abstract
    Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory-demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled 'mapping back' dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS.
    Source

    Schirmer L, Schafer DP, Bartels T, Rowitch DH, Calabresi PA. Diversity and Function of Glial Cell Types in Multiple Sclerosis. Trends Immunol. 2021 Mar;42(3):228-247. doi: 10.1016/j.it.2021.01.005. Epub 2021 Feb 13. PMID: 33593693; PMCID: PMC7914214. Link to article on publisher's site

    DOI
    10.1016/j.it.2021.01.005
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/29776
    PubMed ID
    33593693
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    ae974a485f413a2113503eed53cd6c53
    10.1016/j.it.2021.01.005
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