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Document Type
Journal ArticlePublication Date
2021-03-01Keywords
astrocytesmicroglia
multiple sclerosis
neuroinflammation
oligodendrocytes
transcriptomics
Immune System Diseases
Immunity
Immunopathology
Molecular and Cellular Neuroscience
Nervous System Diseases
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Show full item recordAbstract
Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory-demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled 'mapping back' dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS.Source
Schirmer L, Schafer DP, Bartels T, Rowitch DH, Calabresi PA. Diversity and Function of Glial Cell Types in Multiple Sclerosis. Trends Immunol. 2021 Mar;42(3):228-247. doi: 10.1016/j.it.2021.01.005. Epub 2021 Feb 13. PMID: 33593693; PMCID: PMC7914214. Link to article on publisher's site
DOI
10.1016/j.it.2021.01.005Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29776PubMed ID
33593693Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.it.2021.01.005